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What is the other name for CD4 cells?
T helper cells (TH).
What is the other name for CD8 cells?
Cytotoxic T cells (CTL).
What is the restriction of CD4 cells MHC wise?
CD4 cells are restricted to MHC class II.
What is the restriction of CD8 cells MHC wise?
CD8 cells are restricted to MHC class I.
What is the tissue distribution of MHC class I?
All nucleated cells.
Red Blood Cells have MHC class I on their surface (T/F)...
FALSE (profs looooove this question...).
What is the tissue distribution of MHC class II?
- Antigen presenting cells (B cells, Macrophages, Dendritic cells);
- Activate T helper cells;
- other cells when facing overwhelming inflammation;
A majority of T cells express receptors made up of gamma and delta chains (T/F).
FALSE (actually alpha and beta...).
What seems to restrict gamma-delta T cells?
Non-classical MHC-like molecules.
What factors will influence the quality of the immune response (3):
- antigen type and amount present;
- information passed on by APC;
- immune memory.
What do antibodies recognize?
Epitopes on antigens (8-10 aa).
What does the TCR recognize?
Epitopes in context of self.
Name the 5 types of antibodies.
A, D, E, G, M.
What are the variable cassettes found in heavy chain genes
Leader, Variable, Diversity, Joining, Constant.
What are the variable cassettes found in light chain genes
Leader, Variable, Joining, Constant
What does RSS stand for?
Recombination signal sequence
The nonamer is contiguous with the coding sequence (T/F).
False; it is actually the heptamer.
What composes an RSS?
- a heptamer contiguous with the coding sequence;
- a spacer either 12 or 23 nt long;
- a nonamer;
For a heavy chain, a V gene can recombine next to a J gene (T/F).
FALSE
What is in VDJ-recombinase?
RAG-1 and RAG-2