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29 Cards in this Set

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Abrasion
Wound caused by scraping or friction to the skin's surface.
Angioblast
Endothelial cell that lines vessel walls.
Angiogenesis
Formation of new blood vessels.
Chemotactic agent
Substance that attracts cells.
Chemotaxis
Movement along a chemical gradient.
Closed wound
A wound in which the epithelial integrity has been restored.
Cytokine
Signaling protein during the inflammatory phase of wound healing.
Diapedesis
The movement of PMNs through capillary walls.
Exudate
Mixture of fluid, high levels of protein, and cells.
Fibroblast
Dermal cell that produces collagen, elastin, granulation tissue, and growth factors.
Granulation tissue
Temporary structure composed of vascularized connective tissue that fills the wound void.
Growth factor
Growth-promoting substance that increases or enhances cell size, proliferation, or activity.
Healed wound
A closed wound with tissue strength approaching normal.
Histamine
Chemical mediator released by mast cells which causes vasodilation, increases vessel wall permeability, and attracts other cells to the area.
Inflammation
First phase of wound healing, characterized by rubor, calor, tumor, dolor, and functio laesa; vascular and cellular response to injury of living tissue.
Integrins
Cell surface receptors that allow cells to reversibly bind to the extracellular matrix.
Macrophage
Cell that directs the repair process, secretes growth factors and enzymes, and destroys bacteria and debris.
Margination
When PMNs are pushed to the sides of a vessel wall.
Mast cell
Cell that helps initiate inflammation; secretes histamine, enzymes, and chemical mediators.
Matrix metalloproteases (MMPs)
Proteases that degrade the extracellular matrix.
Maturation and remodeling
phase of wound healing during which collagen matures and reorients along the lines of stress.
Myofibroblast
Cell possessing properties of fibroblasts and smooth muscle cells which cause wound contraction.
Platelet
Cell that helps control bleeding; releases growth factors and chemotactic agents.
PMN (Polymorphonuclear neutrophil)
Cleans the wound; secretes enzymes and inflammatory mediators.
Proliferation
Second phase of wound healing; building and regenerating phase consisting of angiogenesis, granulation tissue formation, wound contraction, and epithelialization.
Prostaglandins
Substances released by injured cells that cause vasodilation.
Scab
Collection of necrotic cells, fibrin, collagen, and platelets that covers a superficial wound.
Transudate
Low-protein collection of fluid caused by increased vascular permeability.
Wound contraction
Process by which myofibroblasts pull wound margins closer together thereby decreasing the size of the defect.