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9 Cards in this Set
- Front
- Back
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Basic characteristics of the disease?
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enveloped, DNA, icosahedral, double stranded, transmitted by saliva
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What tissues is mono restricted to?
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oropharyngeal cells, epithelial cells, B,T lymphocytes, monocytes
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what type of receptor does it use>
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MHC class II- infects b cells
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What determines weather mono will be latent, lytic, or persistant?
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When the virus in endocytosed the genome is transferred to the nucleus, transcribed and replicated, remains as an episome with in the nucleus and when it is transcribed into the genome the genes that are transcribed determine how it will present
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What two ways is mono spread through out the body and in what cells?
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through B cell proliferation, or through the lytic infection which usually happensin the orophayngeal epithelial cells
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what does the EBV do when it infects a B cell?
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it stimulates growth of the cell, prevents apoptosis, and stimulates massive proliferation of a heterophile antibody- this produces lots of T cells (from which the name comes)- to control B cell growth
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what does the ampicillin infection come from?
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all of these spuriously produced antiodies, also acts out against ampicillin in some cases
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What are Downey cells? And what do they cause?
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the T cells produced are a typical and large- their increased size causes swelling of lymph glands, spleen, and liver
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What could happen if the B cell growth is not controlled by T cells?
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this could result in a lymphoma- malaria- Africa Burkitt's lymphoma, china- nasopharyngeal carcinoma- oral hairy leukoplakia
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