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Muscarinic Antagonists (Blockers); Quartenary Amines

Muscarinic Antagonists (Blockers); Quartenary Amines

By ivan.reyesrufo9, Feb 2012

Subjects: 1 block omsi spring tucom2015

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18 Cards in this Set

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Glycopyrrolate (MOA & PK)	MOA - Reversibly inhibits ACh binding to muscarinic receptors	PK - IV; quartenary amine
Glycopyrrolate (CU & T)	CU - IBS; minor diarrhea; block muscarinic effects in periphery	T - Decreased sweating and lacrimation, elevation of body temp, tachycardia, constipation, dry mouth, and blurred vision+ mydriasis, sedation, amnesia, delirium or hallucinations, heart arrhythmias, cutaneous vasodilation; reduced CNS effects
Mepenzolate (MOA & PK)	MOA - Reversibly inhibits ACh binding to muscarinic receptors	PK - PO; quartenary amine
Mepenzolate (CU & T)	CU - IBS; minor diarrhea; block muscarinic effects in periphery	T - Decreased sweating and lacrimation, elevation of body temp, tachycardia, constipation, dry mouth, and blurred vision+ mydriasis, sedation, amnesia, delirium or hallucinations, heart arrhythmias, cutaneous vasodilation; reduced CNS effects
Methscopolamine (MOA & PK)	MOA - Reversibly inhibits ACh binding to muscarinic receptors	PK - PO; quartenary amine
Methscopolamine (CU & T)	CU - IBS; minor diarrhea; block muscarinic effects in periphery	T - Decreased sweating and lacrimation, elevation of body temp, tachycardia, constipation, dry mouth, and blurred vision+ mydriasis, sedation, amnesia, delirium or hallucinations, heart arrhythmias, cutaneous vasodilation; reduced CNS effects
Tridihexethyl (MOA & PK)	MOA - Reversibly inhibits ACh binding to muscarinic receptors	PK - PO; quartenary amine
Tridihexethyl (CU & T)	CU - IBS; minor diarrhea; block muscarinic effects in periphery	T - Decreased sweating and lacrimation, elevation of body temp, tachycardia, constipation, dry mouth, and blurred vision+ mydriasis, sedation, amnesia, delirium or hallucinations, heart arrhythmias, cutaneous vasodilation; reduced CNS effects
Clindinium (MOA & PK)	MOA - Reversibly inhibits ACh binding to muscarinic receptors	PK - PO; quartenary amine
Clindinium (CU & T)	CU - IBS; minor diarrhea; block muscarinic effects in periphery	T - Decreased sweating and lacrimation, elevation of body temp, tachycardia, constipation, dry mouth, and blurred vision+ mydriasis, sedation, amnesia, delirium or hallucinations, heart arrhythmias, cutaneous vasodilation; reduced CNS effects
Trospium (MOA & PK)	MOA - Reversibly inhibits ACh binding to muscarinic receptors	PK - PO/PR/IV; quartenary amine
Trospium (CU & T)	CU - IBS; minor diarrhea; block muscarinic effects in periphery	T - Decreased sweating and lacrimation, elevation of body temp, tachycardia, constipation, dry mouth, and blurred vision+ mydriasis, sedation, amnesia, delirium or hallucinations, heart arrhythmias, cutaneous vasodilation; reduced CNS effects
Propantheline (MOA & PK)	MOA - Reversibly inhibits ACh binding to muscarinic receptors	PK - PO; quartenary amine
Propantheline (CU & T)	CU - IBS; minor diarrhea; block muscarinic effects in periphery	T - Decreased sweating and lacrimation, elevation of body temp, tachycardia, constipation, dry mouth, and blurred vision+ mydriasis, sedation, amnesia, delirium or hallucinations, heart arrhythmias, cutaneous vasodilation; reduced CNS effects
Ipratropium (MOA & PK)	MOA - Reversibly inhibits ACh binding to muscarinic receptors	PK - Inhaled; quartenary amine
Ipratropium (CU & T)	CU - Asthma and COPD	T - Decreased sweating and lacrimation, elevation of body temp, tachycardia, constipation, dry mouth, and blurred vision+ mydriasis, sedation, amnesia, delirium or hallucinations, heart arrhythmias, cutaneous vasodilation; reduced CNS effects
Tiotropium (MOA & PK)	MOA - Reversibly inhibits ACh binding to muscarinic receptors	PK - Inhaled; longer duration than ipratropium; quartenary amine
Tiotropium (CU & T)	CU - Asthma and COPD	T - Decreased sweating and lacrimation, elevation of body temp, tachycardia, constipation, dry mouth, and blurred vision+ mydriasis, sedation, amnesia, delirium or hallucinations, heart arrhythmias, cutaneous vasodilation; reduced CNS effects