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12 Cards in this Set

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What blocks cholinoreceptors that are activated by muscarine?
atropine
What are the actions of the Beta-2 receptors?
accelerate the heart, increase contraction of the heart, relax bronchiolar smooth m., bladder and uterus, gluconeogenesis and glycogenolysis
What are the actions of the alpha receptors?
contract blood vessels, uterus,skin and smooth m., ejaculation of penis, increase apocrine and eccrine sweat glands and cause gluconeogenesis and glycogenolysis
What is the action of M2?
decrease heart rate and contractility, suppresses AV conduction
M2 is a muscarinic receptor (mAchR)
What is the job of the beta and gamma subunits of the G protein?
Beta and Gamma subunits transmit the signal for hyperpolarization on the potassium channel.
M2 receptors
What defines the receptor subtype?
the antagonist that blocks it.
ex: nicotinic and muscarinic receptors
Which receptors contract and relax the eye?
Alpha-1 receptor contracts the radial muscle and the Beta receptor relaxes the circular muscle (SS). M3 contracts both the radial and circular muscle (PS)
SS and PS
What is atropine's action on pelvic visceral smooth m. organs (bladder, uterus and penis)?
It blocks the action of muscarinic agonists administered (SS), but is ineffective in blocking PS responses.
Which muscarinic receptors control the parietal and chief cells of the stomach?
M1
What is the action of the odd numbered muscarinic receptors (mAchR)- M1, M3, M5?
They couple through Gq-G proteins to increase cytosolic calcium levels and are stimulatory to cellular activity.
What is the effect of stimulating vascular mAchR's?
It causes a fall in peripheral resistance which causes decr. BP and reflex tachycardia.
What is the action of pilocarpine?
muscarinic agonist used for acute and chronic glaucoma; topical for miotic action on the eye