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8 Cards in this Set
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- Back
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Levodopa
trade type |
Dopar©
Dopaminergic Agents |
|
Levodopa
MOA |
- Promote dopamine synthesis
- Prevent dopamine breakdown -prevent dopaminergic drug breakdown - Promote dopamine release - Direct activation of dopamine receptors Are for symptom relief & no way curative |
|
Levodopa
results in dyskinesias |
• tremor at rest,
• rigidity, • postural instability, • bradykinesia |
|
Levodopa
Levodopa |
-most common drug treat PD, used for symptom relief, no way curative
-works: crossing BBB & entering dopamine terminals within striatum where is converted into dopamine -much converted/broken down before leaves periphery, so given with Carbidopa |
|
Levodopa
Carbidopa |
inhibits conversion of Levodopa in periphery
|
|
Parkinson’s:
|
-characterized by dyskinesia’s related to imbalance between dopamine & acetylcholine in striatum of extrapyramidal system
-is degeneration of neurons that supply dopamine to striatum in substantia nigra -↑acetylcholine → ↑GABA: →dyskinesia’s common in PD |
|
Benztropine
Trade type |
Cogentin©
Anticholinergic Agents |
|
Benztropine
MOA other sruff |
- Blockade of muscarinic receptors in striatum
-Not 1st line PD treatment , reserved for EPS treatment caused by antipsychotics -reduce tremors & rigidity, not bradykinesia -blocks cholinergic receptors in periphery, causing *dry mouth *blurred vision, photophobia *urinary retention, constipation *tachycardia |
