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70 Cards in this Set
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- Back
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Conjugated equine estrogen (CEE)
What route? |
(Premarin)
Route = Oral estrogen |
|
(Premarin)
What route? |
Conjugated equine estrogen (CEE)
Route = oral estrogen |
|
Synthetic conj estrogen
What route? |
(Cenestin)
(Enjuvia) Route = oral estrogen |
|
(Enjuvia)
What route? |
Synthetic conj estrogen
Route = oral estrogen |
|
(Cenestin)
What route? |
Synthetic conj estrogen
Route = oral estrogen |
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Micronized estradiol
What route? |
(Estradiol)
(Estrace) (Gynodiol) Route = oral estrogen |
|
(Estradiol)
What route? |
Micronized estradiol
Route = oral estrogen |
|
(Estrace)
What route? |
Micronized estradiol
Route = oral estrogen |
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(Gynodiol)
What route? |
Micronized estradiol
Route = oral estrogen |
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Estrone sulfate
What route? |
(Estropipate)
(Ortho-Est) (Ogen) Route = oral estrogen |
|
(Estropipate)
What route? |
Estrone sulfate
Route = oral estrogen |
|
(Ortho-Est)
What route? |
Estrone sulfate
Route = oral estrogen |
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(Ogen)
What route? |
Estrone sulfate
Route = oral estrogen |
|
Esterified estrogen
What route? |
(Estratab)
(Menest) Route = oral estrogen |
|
(Estratab)
What route? |
Esterified estrogen
Route = oral estrogen |
|
What's the difference among:
17-beta-Estradiol 17-beta-estradiol micronized gel 17-beta-estradiol transdermal spray |
17-beta-Estradiol = oral & vaginal estrogen
17-beta-estradiol micronized gel (Estrogel) = transdermal 17-beta-estradiol transdermal spray (Evamist) = transdermal |
|
What's the difference b/n
Synthetic conj estrogens (Cenestin, Enjuvia) Synthetic conj estrogen |
(Cenestin, Enjuvia) = 0.3 mg, 0.45 mg, 0.625 mg, 0.9 mg, 1.25 mg daily
synthetic conj estrogen = not available in 0.45 mg |
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Estradiol transdermal patch
What route? |
(Estraderm)
(Esclim) (Alora) (Vivelle) Route = transdermal |
|
(Estraderm)
What route? |
Estradiol transdermal patch
Route = transdermal patch |
|
(Esclim)
What route? |
Estradiol transdermal patch
Route = transdermal patch |
|
(Alora)
What route? |
Estradiol transdermal patch
Route = transdermal patch |
|
(Vivelle)
What route? |
Estradiol transdermal patch
Route = transdermal patch |
|
What's the difference?
Estradiol transdermal patch (Estraderm, Esclim, Alora, Vivelle) Estradiol transdermal patch (Climara, Fempatch, Menostar) |
(Estraderm, Esclim, Alora, Vivelle) = Apply twice weekly
(Climara, Fempatch, Menostar) = Apply once weekly |
|
Estradiol and levonorgestrel
What route? |
(Climara Pro)
Route = transdermal |
|
(Climara Pro)
What route? |
Estradiol and levonogestrel
Route = transdermal |
|
Estradiol and norethindrone
What route? |
(CombiPatch)
Route = transdermal |
|
(CombiPatch)
What route? |
Estradiol and norethindrone
Route = transdermal |
|
Estradiol topical emulsion
What route? |
(Estrasorb)
Route = transdermal |
|
Does transdermal always mean patch?
|
No.
Can mean patch, spray, gel, emulsion |
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Does tablet always mean through the mouth?
|
No.
ex: Vagifem vaginal tablet |
|
17-beta-estradiol micronized gel
What route? |
(Estrogel)
Route = transdermal |
|
(Estrogel)
What route? |
17-beta estradiol micronized gel
Route = transdermal |
|
17-beta-estradiol transdermal spray
What route? |
(Evamist)
Route = transdermal |
|
What vaginal products are available for HRT?
|
(Local effects)
Estrace vaginal cream Premarin vaginal cream Estring vaginal ring, 17-beta estradiol Vagifem vaginal tablet (Systemic absorption) Femring vaginal ring, estradiol acetate |
|
17-beta-estradiol
What route? |
No Brand name
Oral = 2 mg qd (Estring vaginal ring) Vaginal = 2 mg estradiol ring releases 7.5 mcg/24 hrs; ring remains in vagina for 3 months |
|
What oral combination estrogen-progestin products are available for HRT?
|
Activella
Femhrt Prepro Premphase |
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What are the estradiol/norethindrone HRT products & how do they differ?
|
Activella
1 mg/0.5 mg OR 0.5 mg/0.1 mg Femhrt 2.5 or 5 mcg ethinyl estradiol, 0.5 or 1 mg norethindrone acetate |
|
What's the difference b/n Activella & Femhrt?
What route & type of HRT? |
Activella = Estradiol + norethindrone
Femhrt = Ethinyl estradiol + norethindrone acetate Route = oral combo estrogen-progestin products |
|
What's the difference b/n estradiol & ethinyl estradiol?
|
17 beta estradiol = most produced in women but quickly oxidizes to estrone
Addition of 17 alpha alkyl gp to estradiol struct = blocks oxidation to estrone & becomes a very effective oral agent |
|
What's the difference b/n Prempro & Premphase?
What route & type of HRT? |
Both consists of conj estrogen + medroxyprogestrone
Prempro = varies of each type Premphase = 2 wks of estrogen alone then 2 wks of combo (hence phase) Route = oral combo estrogen-progestin products |
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What are the combination estrogen-androgen products & what are they used for?
|
Estratest HS, Covaryx HS
Estratest, Covaryx HS Use = tx of hotflashes, atrophic vaginitis, menopause |
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How much calcium is contained in calcium citrate?
|
calcium citrate = 24% calcium content
|
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How much calcium is contained in calcium carbonate?
|
calcium carbonate = 40% calcium content
|
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How much calcium is contained in calcium phosphate tribasic?
|
calcium phosphate tribasic = 39% calcium content
|
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What does osteoblast mean?
|
bone formation
|
|
What does osteoclast mean
|
bone destruction
|
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What is the recommended dose of calcium intake per day?
How should it be taken & why? |
1,000 - 1,500 mg / day
take at separate doses of approx 500 mg b/c only approx 500 mg of calcium can be absorbed from the GI tract at a time |
|
What's the difference b/n calcium carbonate and calcium citrate when counseling?
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Calcium carbonate = take with food to facilitate absorption
Calcium citrate = admin w/o regards to meals |
|
What Calcium citrate products are available?
|
Citracal
Citracal + Vitamin D |
|
What calcium carbonate products are available?
|
Caltrate 600
Titralac (chewable, liquid) Tums (chewable) Mylanta Supreme liquid |
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What calcium carbonate + vitamin D products are available?
|
Caltrate 600 + D
Calcilyte + vitamin D Oscal + vitamin D Viactiv chews |
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What calcium phosphate tribasic products are available?
|
Posture
Posture-D |
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What bisphosphonates are available for osteoporosis?
|
Alendronate (Fosamax)
Risedronate (Actonel) Ibandronate (Boniva) Zoledronic acid (Reclast) |
|
Alendronate
|
(Fosamax)
|
|
Risedronate
|
(Actonel)
|
|
Ibandronate
|
(Boniva)
|
|
Zoledronic acid
|
(Reclast)
|
|
What should be counseled when taking bisphosphonates?
|
Take w/ a full glass of water 30 - 60 minutes prior to first meal of the day & 30 - 60 minutes b/f any other medications (separate calcium supplements & antacids by 1 hr)
Remain upright for 30 minutes after ingestion |
|
What are some Drug Interactions of bisphosphonates?
|
calcium supplements & antacids = decrease bisphosphonate effect
Ranitidine = increase bisphosphonate effect bisphonates = increase ASA toxicity |
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What medication is an estrogen agonist-antagonist (selective estrogen receptor modulator)?
|
Raloxifene (Evista)
|
|
Raloxifene
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(Evista)
|
|
What are some drug interactions with Evista?
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Ampicillin & Cholestyramine = decrease raloxifene effect
raloxifene = increase warfarin effects |
|
What is the mechanism of action of calcitonin (Miacalcin, Fortical)?
|
Inhibits bone resorption by binding to osteoclast receptors
|
|
What is the most common SE of Miacalcin or Fortical?
|
facial flushing and hand flusing
|
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What are some drug interactions of Miacalcin or Fortical?
|
calcitonin decreases lithium effects
|
|
Calcitonin
|
(Miacalcin)
(Fortical) |
|
What drug is a parathyroid hormone?
|
teriparatide (Forteo)
|
|
What is the MOA of teriparatide?
|
increases the rate of bone formation by stimulating osteoblasts, thereby increasing bone mass density & decreasing risk fractures
|
|
Who is contraindicated for using raloxifene?
|
Patients with a hx of venous thromboembolism b/c DVT & pulmonary embolism = AE (duh!)
|
|
Who is contraindicated for teriparatide?
|
increased risk of osteosarcoma (risk of osteosarcoma seen in animal model)
patients who have received radiation to the bone adolescents or young adults with open epiphyses individuals with Paget's disease |
