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9 Cards in this Set
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- Back
- 3rd side (hint)
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What is the chemical name for aspirin?
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Acetylsalicylic acid (ASA)
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Aspirin, with a capital "A", remains a registered trademark of Bayer in Germany, Canada, Mexico, and in over 80 other countries. |
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What are the functional classes of aspirin?
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- Salicylate
- Analgesic - Antiplatelet - Antipyretic |
Salicylic acid is found in willow bark and is the source of the name, from the Latin "salix" meaning "willow". |
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What is the mechanism of action of aspirin?
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- Aspirin blocks the production of cyclooxygenase (COX), the precurser to thromboxane A2 (which is the physiological inducer of platelet aggregation).
- As an anti-inflammatory agent it appears to be involved in the inhibition of prostaglandin synthesis. Its anti-inflammatory actions also contribute to its analgesic effects. - Aspirin also acts to reduce fever by causing centrally-mediated peripheral vasodilation and sweating. |
Asprin has other modes of action which are less well-understood, including affecting mitochondria and reducing inflammation by at least two other mechanisms. |
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What are the listed indications for aspirin?
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Suspected AMI, chest pain, or ACS
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In non-prehospital arenas, aspirin has been used as a prophylactic for DVT in air travellers, to treat Kawasaki disease in children and investigated as an anti-cancer drug. |
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What are the listed contraindications for aspirin?
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Hypersensitivity
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Hypersensitivity to ibuprofen or naproxen may indicate hypersensitivity to aspirin. |
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What are the listed precautions for aspirin?
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Peptic ulcer disease, asthma
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Some sources include hemophilia and other disorders likely to result in excessive bleeding (such as Dengue fever). |
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What are the listed side effects for aspirin?
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Overdose may result in considerable toxicity with dizziness, N/V, abdominal pain, thrombocytopenia, easy bruising, and/or metabolic acidosis.
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Use of aspirin in children and teenagers can increase the likelihood of them devloping Reye's syndrome. Large doses of aspirin can cause tinnitus. |
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What are the listed interactions for aspirin?
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- Incompatible with uricosuric agents
- Anticoagulants increase the risk of bleeding |
Ibuprofen can negate the antiplatelet effect of aspirin used for cardioprotection and stroke prevention. |
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What is the dosage and route of aspirin?
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160 - 325mg PO (chewable) tablets
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"Baby aspirin" are typically 81mg |
