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10 Cards in this Set
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What is the best-known trade name for vasopressin?
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Pitressin
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Vasopressin is also known as argipressin, arginine vasopressin (AVP) and antidiuretic hormone (ADH). |
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What is the functional class of vasopressin?
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Hormone (ADH), vasopressor
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Vasopressin is mainly produced in the paraventricular nucleus (PVN) and supraoptic nucleus (SON) of the hypothalamus. It is very similar in structure to oxytocin. |
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What is the mechanism of action of vasopressin?
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Vasopressin possesses pressor and antidiuretic properties:
- It increases nephron distal tube reabsorption of water. - In unnaturally high doses, it acts as a non-adrenergic vasoconstrictor by stimulation of smooth muscle receptors. - It is used as an alternative to epinephrine during CPR. |
Vasopressin has also been identified in memory formation and the regulation of social bonding and behavior. |
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What are the listed indications for vasopressin?
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Cardiac arrest
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Vasopressin is also used in the hospital treatment of septic shock. |
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What are the listed contraindications for vasopressin?
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- Chronic nephritis
- Ischemic heart disease - PVCs - First stage of labor |
And, of course, known hypersensitivity. |
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What are the listed precautions for vasopressin?
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Use with caution in patients with:
- Epilepsy - Migraine - Asthma - Heart failure - Angina pectoris |
Some sources also list renal insufficiency as a precaution. |
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What are the listed side effects for vasopressin?
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- N/V
- Abdominal cramps - HTN - Bradycardia - PACs - MI |
PACs (premature atrial contractions) are a benign arrhythmia that occurs in the atria. They are not as serious as premature ventricular contractions (PVCs) and usually require no medical care. |
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What are the listed interactions for vasopressin?
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- Epinephrine
- Heparin - Alcohol - Phenytoin - Thiazide diuretics - Carbamazepine - Neostigmine |
May decrease antidiuretic effects: - Epinephrine - Heparin - Alcohol - Phenytoin May increase antidiuretic effects: - Thiazide diuretics - Carbamazepine May increase vasoconstriction: - Neostigmine |
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What is the dosage and route of vasopressin?
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40 units IVP/IO (single dose only)
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Vasopressin international units are defined by comparing the pressor effects to that of the USP Posterior-pituitary Reference Standard. 1mg of vasopressin is 600 units. |
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When should vasopressin be used in a cardiac arrest situation?
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May replace first or second dose of epinephrine in cardiac arrest.
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This is for adult arrest only (AHA). |
