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63 Cards in this Set
- Front
- Back
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Ascending Pressure,
Vibration, Touch, Proprioceptive sensation |
Dorsal Column
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Dorsal Column First-order neuron
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Dorsal root ganglion
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Dorsal column travels ipsi/contralateral
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Ipsilateral
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Synpase 1 for Dorsal Column
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Ipsilateral Cutaneus/ Gracilis
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2nd Order Neuron for Dorsal Column
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Desscuates in medulla and ascends contralaterally in medial leminscus
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Synapse 2 for Dorsal Column
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VPL of thalamus
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3rd Order Neuron for Dorsal Column
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Sensory Cortex
-Broadmann's Area 3 1 2 |
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Transection of dorsal column tract
above the sensory descussation |
Contralateral loss
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Transection of dorsal column tract
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Ipsilateral Loss
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Ascending Pain
Temperature sensatiom |
Spinothalamic tract
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The lateral spinothalamic tract recieves input from...
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fast (A-delta) and slow-conducting (C-fibers) pain fibers
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Synapse 1- Spinothalamic tract
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Ipsilateral Gray matter
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2nd Order neuron for Spinothalamic tract
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Decusstes at anterior white commissure--> ascends contralaterally
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Synapse 2- Spinothalamic tract
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VPL of thalamus
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3rd Order neuron of spinothalamic tract
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Sensory cortex
Brodmann's Area 3 1 2 |
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Descending Voluntary Movements of contralateral limbs
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Lateral corticospinal tract
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Babinski sign is what tract
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Lateral corticospinal tract
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1st order neuron Lateral corticospinal tract
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UMN cell body in primary motor cortex descends ipsilaterally
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Lateral corticospinal tract decussates where
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Descussates at caudal medulla
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Synapse 1- Lateral Corticospinal Tract
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Cell body of Anterior Horn
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2nd Order Neuron
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LMN: leaves spinal cord
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Synapse 2- Lateral Corticospinal
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Neuromuscular Junction
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Spastic paresis with pyramidal signs (Babinski's sign)
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UMN Lesion
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Weakness UMN/LMN
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Both!!
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Atrophy UMN/LMN
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LMN
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Fasciculation UMN/LMN
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LMN
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Hyperreflexes UMN/LMN
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UMN
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Hyporeflexes UMN/LMN
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LMN
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Hypertonia UMN/LMN
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UMN
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Hypotonia UMN/LMN
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LMN
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Clasp knife spasticity
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UMN
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Combined UMN and LMN disease
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AML Lou Gehrig's Disease
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Defective superoxide demutase 1 produces free radical injury of neurons
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Lou Gehrig's disease
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Mutations on chromosome 21
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Lou Gehrig's disease
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Clinical finding for Lou Gehrig's disease
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UMN- spasticity, Babinskis
LMN- Muscle weakness- begins with atrophy of the hands |
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GAA expansion
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Fredrich's Ataxia
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Mitochondrial iron hemostasis, cells are more prone to apoptosis
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Fredrich's Ataxia
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Fredrich Ataxia site of demyelination(5)
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-Dorsal Root Ganglion
Posterior Column Spinocerebellar tract Lateral corticospinal tract Large Sensory Peripheral Neurons |
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Progressive ataxia
Loss of deep tendon reflexes Loss of vibratory sensation and proprioception Muscle weakness in the leg |
Fredrich's Ataxia
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Degeneration of dorsal roots and column
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Tabes Dorsalis
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Associated with:
Charcot's Joint Shooting Pain Argyll Robertson Pupils |
Tabes Dorsalis
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Cause of death in Fredrich's Ataxia
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Hyperthrophic Cardiomyopathy
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Infraction of the anterior two-thirds of the spinal cord but spares the dorsal column and dorsal horns
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Anterior spinal artery occlusion
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Hemisection of the spinal cord
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Brown-Sequard Syndrome
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Brown-Sequard Findings (5)
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Ipsilateral UMN signs below lesion
Ispilateral loss of tactile, vibration, proception sense below lesion Contralateral loss of pain and temperature below lesion Ispilateral loss of all sensation at the level of the lesion LMN signs at the level of the lesion |
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Horner's syndrome where is the lesion?
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Above T1
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Horner's Syndrome symptoms
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Ptosis
Anhidrosis Miosis |
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Degneration of posterior column and lateral corticospinal tract demyelination
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B12 deficiency
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B12 Deficiency CNS Sx
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Dementia
peripheral neuropathy |
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Hemorrhages with hemosiderin deposits in Mamillary bodies
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Wernicke's Korsakoff
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Autoimmune demyelination syndrome
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Guillain-Barre
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Rapidly progressive ascending motor weakness
Starts in proximal muscle and eventually includes distal muscle |
Guillain Barre
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Commonly preceded by Mycoplasma pneumoniae, Campylobacteria jejuni
HIV EBV CMV |
Guillain-Barre
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Caused by a virus that replicated in the oropharynx and small intestine before spreading through the bloodstream to CNS
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Poliomyelitis
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Where is the destruction in Polio
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Anterior Horn of the spinal cord, LMN destruction
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Malaise
Headache Fever Nausea Abdominal Pain Sore throat LMN lesions |
Polio
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CSF Finding in Polio
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CSF with lymphocytic pleocystosis
ad slight elevations of proteins |
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Infantile spinal muscular atrophy
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Werdnig-Hoffmann Disease
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Floppy Baby
Tongue fasiculation Median age of death at 7 months |
Werdnig-Hoffmann Disease
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Demyelination of CNS due to destruction of oligodendrocytes
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PML
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Associated with JC virus
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PML
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Multifocal perivenular inflammation and demyelination after infection
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Acute disseminated encephalomyelitis
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progressive hereditary nerve disorders related to the defective production pf proteins involved in the structure and function of peripheral nerves
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Charcot-Marie-Tooth disease
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