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7 Cards in this Set
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- Back
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What disease is this paper over?
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Parkinson's
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What question are they asking?
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Why does DBS work and why doesn't it always work?
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How did they induce Parkinson's in rats?
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6-OHDA + amphetamines
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Method?
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Using optogenetics to see what DBS is doing
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Halorhodopsin?
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Cl- pump --> hyperpolarization
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Is DBS modifying glia?
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Ca++, ChR2, phenotype of rat doesn't change, glia not involved
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Afferent fibers?
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figure 6 - deliver light to M1 cortex - conclude that this is area of cortex involved w/ DBS - altering afferent fibers
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