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12 Cards in this Set
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- Back
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When do you start a patient on an AED for seizures?
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After 2 unprovoked seizures.
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Ideally, how many AEDs do you want the patient to be on?
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ONE -- 70% of ppl will be controlled on monotherapy, adding second drug will control 5% more, but if three drugs don't control, consider surgery.
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How do you dose an AED?
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Start with monotherapy, if side effects too bad, lower the dose and add second AED. Continue taper until second drug becomes monotherapy.
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Phenytoin = Dilantin
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1. Na channels
2. partial 3. gingival hyperplasia, hirsutism, ataxia |
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What happens if you infuse Phenytoin too fast?
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CARDIAC ARRHYTHMIA, hypotension
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Which AED is used ppx to reduce incidence of seizure after a head trauma?
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PHenytoin (Dilantin)
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Carbamazepine = Tegretol
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1. Na channel
2. partial, trigeminal neuralgia 3. hyponatremia, agranulocytosis, diplopia |
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Valproic acid = Depakote
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1. Na channel, GABA rec
2. partial, gen, absence 3. GI sxs, tremor, wt loss, hair loss, hepatotox, thrombocytopenia, teratogen (neural tube defects) |
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Phenobarbital
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1. GABA rec
2. partial, generalized 3. sedation |
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Ethosuximide = Zarontin
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1. T-type Ca channel
2. absence 3. GI sxs |
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Gabapentin = Neurontin
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1. unknown mechanism
2. partial 3. sedation, ataxia |
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Lamotrigine = Lamictal
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1. Na channel, glutamate rec
2. partial, generalized 3. rash, Stevens-Johnson synd |
