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18 Cards in this Set

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what is the definition of MS?
MS is a chronic inflammatory demyelinating disease of the CNS
what are the sites of lesion?
cerebrum
brainstem
cerebellum
optic nerve
spinal cord
What is the nature of lesions in MS?
-Perivascular cuffing and parenchymal infiltration with T lymphocytes and macrophages

-primary demyelination
-loss of oligodenrocytes
-axonal transection
-axonal degeneration
-gliosis
what is the role of EBV in MS?
EBV is a prerequisite for the development of MS.
What is the treatment of Mild Relapse of RR-MS?
nil
Treatment for SP-MS and PP-MS?
IV high dose methylprednisone.
Treatment for RR-MS not responding to IFN and glatiramer?
Natalizumab
Treatment for RR-MS intolerant to IFN-B?
Glatiramer acetate
Treatment for RR-MS?
Interferon B
Treatment for Mod-severe relapse of RR-MS?
IV high dose methylprednisone
How does Natalizumab work?
Monoclonal antibody against alpha4beta1 integrin.

Inhibits entry of circulating lymphocytes and monocytes into CNS.
What is the side effect of Natalizumab?
Progressive multifocal leukoencephalopathy.

Rebound effect with increased autoimmune attack on CNS 3 months after cessation of treatment.

Hypersensitivity reaction.
How do you treat spasticity?
Baclofen
How do you treat neurogenic pain?
Amitriptyline
Gabapentin
how do you treat epilepsy in MS?
sodium valproate
How do you treat persistent severe fatigue not due to depression?
Amantadine
Name the type of MS?
1) relapsing-remitting
2) primary progressive
3) secondary progressive
what is the investigation of choice for diagnosing MS?
Brain/spinal MRI