non steroidal anti-inflammatory drugs

irreversible inactivation of cyclooxygenase.
action- anti-inflammatory, inhibit platelet aggregation, MI.
SidEf-
normal dos- GI bleeding.
large dose- dizziness, deaf, tinnitus, comp respiratory alkalosis.
toxic dos- uncomp respiratory & metabolic acidosis.
t1\2- 3-5h

indication- pain, arthritis, inflammation.
SidEf- Dyspepsia (indigestion), nausea, vomiting, GI damage (for chronic), skin reaction, hemorrhage, reversible renal insufficiency, nephropathy, liver & bone disorder (less common), bronchospasm (if aspirin sensitive asthma).
less GIT irritation then aspirin.
long acting (then aspirin).
t1\2- 8-13h

indication- arthritis, primary dysmenorrhea, fever, analgesic in inflammation.
SidEf- Dyspepsia (indigestion), nausea, vomiting, GI damage (for chronic), skin reaction, hemorrhage, reversible renal insufficiency, nephropathy, liver & bone disorder (less common), bronchospasm (if aspirin sensitive asthma).
first choice drug, lowest SidEf.
t1\2- 2h

indication- pain, fever, inflammation, stiffness, primary dysmenorrhea.
SidEf- Dyspepsia (indigestion), nausea, vomiting, GI damage (for chronic), skin reaction, hemorrhage, reversible renal insufficiency, nephropathy, liver & bone disorder (less common), bronchospasm (if aspirin sensitive asthma).
same as Ibuprofen but stronger and higher chance of SidEf.
t1\2- 14h

indication- analgesic, antipyretic, weak anti-inflammatory.
SidEf- in toxic amount stomach bleeding, nausea & vomiting and fatal liver damage.
t1\2- 2-4h

indication- arthritis, primary dysmenorrhea, fever, analgesic in inflammation.
SidEf- Dyspepsia (indigestion), nausea, vomiting, GI damage (for chronic), skin reaction, hemorrhage, reversible renal insufficiency, nephropathy, liver & bone disorder (less common), bronchospasm (if aspirin sensitive asthma).
moderate potency and GIT effect.
t1\2- 1-2h

indication- arthritis, primary dysmenorrhea, fever, analgesic in inflammation.
SidEf- Dyspepsia (indigestion), nausea, vomiting, GI damage (for chronic), skin reaction, hemorrhage, reversible renal insufficiency, nephropathy, liver & bone disorder (less common), bronchospasm (if aspirin sensitive asthma).
high incidence of headache & dizziness.
t1\2- 2h

indication- arthritis, primary dysmenorrhea, fever, analgesic in inflammation.
SidEf- Dyspepsia (indigestion), nausea, vomiting, GI damage (for chronic), skin reaction, hemorrhage, reversible renal insufficiency, nephropathy, liver & bone disorder (less common), bronchospasm (if aspirin sensitive asthma).
efficacy as ibuprofen, moderate risk of SidEf.
t1\2- 5h

indication- arthritis, primary dysmenorrhea, fever, analgesic in inflammation.
SidEf- Dyspepsia (indigestion), nausea, vomiting, GI damage (for chronic), skin reaction, tinnitus, hemorrhage, reversible renal insufficiency, nephropathy, liver & bone disorder (less common), bronchospasm (if aspirin sensitive asthma).
t1\2- 45h

indication- arthritis, primary dysmenorrhea, fever, analgesic in inflammation.
SidEf- Dyspepsia (indigestion), nausea, vomiting, GI damage (for chronic), skin reaction, hemorrhage, reversible renal insufficiency, nephropathy, liver & bone disorder (less common), bronchospasm (if aspirin sensitive asthma).
steady state plasma C after 2 weeks.
t1\2- 72h

indication- arthritis, primary dysmenorrhea, fever, analgesic in inflammation.
SidEf- Dyspepsia (indigestion), nausea, vomiting, GI damage (for chronic), skin reaction, hemorrhage, reversible renal insufficiency, nephropathy, liver & bone disorder (less common), bronchospasm (if aspirin sensitive asthma).
possibly fewer GIT effects then other.
t1\2- 7h

indication- arthritis, primary dysmenorrhea, fever, analgesic in inflammation.
SidEf- Dyspepsia (indigestion), nausea, vomiting, GI damage (for chronic), skin reaction, hemorrhage, reversible renal insufficiency, nephropathy, liver & bone disorder (less common), bronchospasm (if aspirin sensitive asthma).
possibly fewer GIT effects then other.
t1\2- 20h

specific COX-2 inhibitor

indication- arthritis, primary dysmenorrhea, fever, analgesic in inflammation.
SidEf- Dyspepsia (indigestion), nausea, vomiting, GI damage (for chronic), skin reaction, hemorrhage, reversible renal insufficiency, nephropathy, liver & bone disorder (less common), bronchospasm (if aspirin sensitive asthma).
new compound, markedly less GIT toxicity.
t1\2- 11h

Aspirin Diclofenac
Diflunisal Indometacin
Ibuprofen Tolmetin
Naproxen Piroxicam
Paracetamol Tenoxicam
Etodolac Meloxicam
Celecoxib