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7 Cards in this Set
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Monoclonal Antibody Drugs:
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Rituximab
Trastuzamab Gentuzumab Bevacizumab Cetuximab |
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Rituximab
Receptor and AE |
Anti CD 20 (therefore anti B-Cell)
NHL and CLL AE: Immunosuppressive - black box re: hepatitis react. |
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Trastuzumab
Receptor and AE |
(aka Herceptin) -> Her2Neu Receptor
AE: Cardio toxicity |
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Gemtuzumab
Receptor and AE |
CD-33; AML
myelosuppression Hepatotoxicity |
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Bevicizumab
Receptor and AE |
VGEF (colon cancer)
BLACK BOX: impaired wound healing, GI perforation |
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Cetuximab
Receptor and AE |
EGFR (Epithelial Growth Factor Receptor)
AE: acneiform rash (however, this is an indicator for better response) |
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Monoclonal Abs
MOA: |
Apoptosis
Complement mediated cytotoxicity Ab Dependent cellular toxicity Radiolabeled Ab Chemo-conjugated Ab |
