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22 Cards in this Set
- Front
- Back
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3 Cancer Charecteristics
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1. Loss of Contact Inhibition
2. Uncontrolled Proliferation 3. Loss of Differentiated Function 4. Increased Growth Factor |
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p53
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1. Halts Cell Cyle
2. Facilitate DNA repair 3. Activates CDK-Inhibitor |
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Carciogenesis Stage - Promotion
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Reversible/Epigenic
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Philadelphia Chromosome
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FCR/ABL Fusion
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Inhibit CDK-Cyclin
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1. cAMP
2. Contact Inhibition 3. p21 |
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Oncongenes
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Activate Proliferation
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Tax Protien
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HTLV1
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G1/S Checkpoint
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regulated by extracellular signals
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Dominant Mutation
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Proto conversion
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prB inhibited
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Phosphorylated state
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Adults
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No Telomerase activity
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Telomerase Limiting
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hTERT
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Pivotal Checkpoint after Death
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CYP-C
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Apoptopic Pathway after Chemo
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p-53
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CDK-Cyclin
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Cell Cycle Progression
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Knudson 2-hit
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2nd hit involves chromosomal loss
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Apoptopic Pathway
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TNF-Mediated
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Proliferation
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RTK
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Immortolization
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Telomerase
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Angiogenesis
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Endothelial Cells
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DNA repair
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Microsatelite
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Apopotosis
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BCL-2
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