Opioids and their receptors

By ritooo.c9, Nov 2009

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What are neuropeptides?	small proteins which act as NTs and bind to GPCRs
What breaks down neuropeptides?	Peptidases
What are the three opioid receptors?	mu kabba delta	opioids have 3 prepro-sequences all from the same precursor
What does GPCR inhibition of adenylyl cyclase do?	decreases cAMP (coupled to opening K channels) causing hyperpolarisation
MOA of opioid receptor	activates Gai--> inhibits adenylyl cyclase --> decreases cAMP which either decreases Ca conductance or increase K conductance
Opioids are:	compounds which bind to opioid receptors	Have analgesic effects
Opiates are	compounds derived from opium poppy
Name an opioid antagonist	Naloxone	treats overdose of opioid and addiction
Morphine passes BBB with difficulty why?	Its amphoteric	codeine and heroin can pass through easily
Name some opioids	morphine, codeine, heroin
Side effect of opioids	respiratory depression: breathing rate decreases
codeine is naturally occurring and is converted to?	morphine by CYP2D6
What is used to treat morphine addicts?	Methadone - opioid agonist --> no euphoric effects

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