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29 Cards in this Set

  • Front
  • Back
what is a virus?
obligate intracellular parasites of living cells
what can virus infect?
animals, plants, bacteria, fungi, protozoa
what kind of genetic material they have?
DNA or RNA (not both)
are viruses diploid or haploid
all haploid except retrovirus
structure?
capsid-protien capsomers
virus core-genetic material
possible envelope
envelope is?
lipid memb. of proteins
host cell memb.+ virus proteins
Mutations:
Strain
Type
Variant
S-same virus, isolated diff local
T-same virus, antibody detect diff(serotypes)
V-phenotype diff. from wild type
Reason for mutation in viruss
no proofreading by viral RNA polymerase
Recombination vs Reassortment
comb- 2 distinct genomes

sort- 2 segmented genomes (always RNA)
Order of virus replication
Recog of cell
Attachment
Penetrate
Uncoat
Synthesize protein
assembly
release from host cell

from 8 h to 36h
kinds of penetration
during replication
direct penetration-naked only
fusion-enveloped
endocytosis-both
where genetic info replicated
DNA--> nucleus
x- pox--> cytoplasm

RNA-->cytoplasm
x- retrovirus-->nucleus
Virus damage:
Cytopathic effects?
CE:
Inclusion bodies
syncytium formation
stopping cellular processes
membrane permeability
lysis
apoptosis
Virus damage:
Non-cytopathic effects?
altered shape
detachment from the substrate
transformation
Diagnose viral infection
methods
direct examination
serological methods-ELISA, western blot
Molecular methods
cultivation of viruses
classification of viruss
Order
Family
Subfamily
Genus
Species
Virales
viridae
virinae
virus
disease-virus
prevent control viral disease
quarantine
hygiene
vector control-mosquito
change life
immunization
antiviral chemotherapy
types of vaccines
which not given to immuno?
live
inactivated

..think about it moron
VAERS? is
Vaccine adverse event reporting system
write which ones live and which dead
later
types of antiviral drugs
9 kinda
nucleoside analogs...
non nucleoside reverse transcriptase inhibitors
antisense
topical immune modulators
interferon alpha
ion channel inhibs of M2 proteins and neuraminidase
pyrimidines
other...
Drugs to treat:
HSV and VZV
Acyclovir
Valacyclovir
Famciclovir
Foscarnet
Trifluridine
n-Docosanol
Penciclovir
Drugs to treat:
CMV
Ganciclovir
Valganciclovir
Foscarnet
Cidofovir
Fomivirsen
HHV8
INF-a
HPV
INF-a
Imiquimod
HBV
INF-a
lamivudine
Adefovir
HCV
INF-a
PEG-INF-a
INF-a + Ribavirin
PEG-INF-a + Ribavirin
RSV
Ribavirin
Palivizumab
Influenza virus
Influenza A:
Amantadine & Rimantadine
Influenza B:
Zanamivir & Oseltamivir