Pancreas

Autoimmune pancreatitis is also known by what other name?

What autoimmune diseases are associated with lymphoplasmacytic sclerosing pancreatitis?

Do the osteoclast-like giant cells in undifferentiated carcinoma wiht osteolcast-like giant cells stain with keratin?

____ are to CEA
as
Pseudocysts are to _____

This tumor is commonly found in young women, lacks CEA in cyst fluid, grossly characterized by solid and cystic components. 10-15% present with liver metastasis.

Solid pseudopapillary IHC:
PR
CD56
CD10
alpha-1-antitrypsin
NSE
beta-catenin
Keritins
Chromogranin

This tumor may present clinically as skin rash, normochromic/normocytic anemia, glossitis, stomatitis, mild diabetes mellitus.

This tumor may present with multiple gastric and/or duodenal ulcers.

This tumor presents with severe watery diarrhea with hypokalemia and achlorhydria.

Insulinoma is to small and without metastasis
as
____ is to larger (mean 7.5 cm) size with metastasis (70%) at time of diagnosis

What two factors are most important in predicting tumor aggressiveness in pancreatic endocrine tumors?

Low-grade pancreatic endocrine tumors have ____ and ____ mitosis ___.

Intermediate-grade pancreatic endocrine tumors have ___ and ___ mitosis ___.

This pancreatic tumor may present with multiple skin nodules showing fat necrosis on biopsy and polyarthralgia. Liver metastasis is often present at diagnosis.

Mutation in this protooncogene is seen in over 90% of pancreatic ductal adenocarcinoma.

This pancreatic tumor has a bimodal distribution of ages (peaks at 4 and 30), is more common in Asians, may be associated with increased AFP, may rarely be associated with BWS or FAP, and unlike other childhood tumors, the cure is fairly low with 5-year survival under 25%.

20% of this lesion is associated with mutation in codon 12 of Kras.

Duodenal adenocarcinoma:
CK20
CDX2
MUC1
MUC2
MUC5AC

Pancreatic adenocarcinoma:
CK20
CDX2
MUC1
MUC2
MUC5AC

What is the 5-year survival of pancreatic ductal adenocarcinoma?

How many Americans die of pancreatic cancer per year?

Pancreatic carcinoma is the ___ leading cause of cancer death in America.

What percent of pancreatic adenocarcinoma is related to BRCA mutation?

The ovarian stroma of MCN stains muscle markers?

This pancreatic tumor tends to involve perimenopausal women (mean age 48), is in the body/tail, with 20-30% associated with carcinoma (20% invasive). A coexisting ovarian tumor is very uncommon, and should raise the possibility of metastasis to the ovary.

Are serous cystadenoma PAS positive?

Most common site for heterotopic pancreas.

What is nesidioblastosis?

This disease is associated with morphological changes in the islets of Langerhans including a decrease in the number and size of islets, enlargement of nuclei with irregularities and hyperchromasia. Other changes include per-insular and intrainsular lymphocytic infiltration and mild acinar atrophy.

This disease is associated with amyloid deposits in the islets of Langerhans.

Cystic fibrosis is due to mutation in what gene on what chromosome?

What percentage of people with CF have pancreatic insufficiency?

What is the most common lethal inherited disorder among whites?

Histological changes in the pancreas found in this disease include hyperviscous secretions precipitating in the ducts and leading to obstruction-related chronic pancreatitis, including fibrosis, acinar atrophy and ductectasia.

Histological changes in this disease include mononuclear cells admixed with eosiniophils involving the interstitial tissue, lymphocytes involving hte vascualr walls, especially localizing in the subendothelial space and uplifting hte endothelium, some mononuclear cells involving the acinar and ductal epithelium with sparing of the islets.

Hereditary pancreatitis is autosomal ____ and caused my mutations in ___ and ___.