PATH WINTER Leukemias and Lymphomas Flash Cards

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Title:	PATH WINTER Leukemias and Lymphomas
Description:	Winter
Number of Cards:	34
Save Count:	0
Author:	naf2p12
Created:	2011-12-14
Tags:	path
Private	No

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- Question
- Answer
- Side 3

- Anaplastic Large Cell Lymphoma
  
  Phenotype
  Morphology
  Course
  Assoc
  Clinical
- Anaplastic Large Cell Lymphoma
  
  Phenotype: CD2, 7, 3
  Morphology: ALK, Nodal
  Course: Childhood
  Assoc:Looks like Metastatic
  Clinical: Good Prognosis
- Adult T Cell Lymphoma
  
  Phenotype
  Morphology
  Course
  Assoc
  Clinical
- Adult T Cell Lymphoma
  
  Phenotype: CD2, 4
  Morphology: Extramodal = Skin, CNS demyelination
  Course: n/a
  Assoc: HTLV -1, Carribean, Hypercalcemia
  Clinical: Subacute w/ about 1 yr survival, no cure
- Large Granular Leukemia Lymphoma
  
  Phenotype
  Morphology
  Course
  Assoc
  Clinical
- Large Granular Leukemia Lymphoma
  
  Phenotype: CD2, 3, 8
  Morphology: Splenomrgal, +BM
  Course: Indolent
  Assoc: Pancytopenia +RA
  Clinical: n/a
- Mycosis Fungoides Lymphoma
  
  Phenotype
  Morphology
  Course
  Assoc
  Clinical
- Mycosis Fungoides Lymphoma
  
  Phenotype: CD4
  Morphology: Skin Patch --> Plaque
  Course: Indolent 8+ years
  Assoc: Pautrier microabsceses
  Clinical: Looks like a fungal skin infection
- Sezary Cell Lymphoma
  
  Phenotype
  Morphology
  Course
  Assoc
  Clinical
- Sezary Cell Lymphoma
  
  Phenotype: CD4
  Morphology: Leukemia from start
  Course: Aggressive
  Assoc: Red Man Exfoliation
  Clinical: n/a
- Follicular Common Lymphoma
  
  Phenotype
  Morphology
  Course
  Assoc
  Clinical
- Follicular Common Lymphoma
  
  Phenotype: CD19, CD20, 14, 18, Translocation BCl-2 blocks apoptosis
  Morphology: Nodal aka "Follicles"
  Course: Indolent 8+ years
  Assoc: n/a
  Clinical: Incurable
- Large B Common Lymphoma
  
  Phenotype
  Morphology
  Course
  Assoc
  Clinical
- Large B Common Lymphoma
  
  Phenotype: CD19, CD20, May evolve from preexisting lymphomai, CLL Follicular BCL6
  Morphology: Nodal Extranodal, eg. waldyers ring abdomen
  Course: Aggressive < 6 months
  Assoc: n/a
  Clinical: 50% cure rate
- Burkitt-African/Endemic Lymphoma
  
  Phenotype
  Morphology
  Course
  Assoc
  Clinical
- Burkitt-African/Endemic Lymphoma
  
  Phenotype: CD19, CD20, CD10, 8:14 translocation --> MYC activation
  Morphology: Extranodal: face
  Course: Aggressive
  Assoc: EBV
  Clinical: Potentially curable, Starry Sky
- Burkitt-Sporadic Lymphoma
  
  Phenotype
  Morphology
  Course
  Assoc
  Clinical
- Burkitt-Sporadic Lymphoma
  
  Phenotype: CD19, CD20, CD10, 8:14 translocation --> MYC activation
  Morphology: Child Abdomen, IC valve, ovaries
  Course: Aggressive
  Assoc: No EBV
  Clinical: Potentially curable, Starry Sky
- Burkitt HIV Lymphoma
  
  Phenotype
  Morphology
  Course
  Assoc
  Clinical
- Burkitt HIV Lymphoma
  
  Phenotype: CD19, CD20, CD10, 8:14 translocation --> MYC activation
  Morphology: Nodal or Extranodal
  Course: Aggressive
  Assoc: +/- EBV
  Clinical: Potentially curable, Starry Sky
- Mantle Lymphoma
  
  Phenotype
  Morphology
  Course
  Assoc
  Clinical
- Mantle Lymphoma
  
  Phenotype: CD19, CD20 + others, 11:14 BCL1 (Cyclin D)
  Morphology: Nodal + BM
  Course: Intermediate
  Assoc: n/a
  Clinical: About 50% cure maybe, aggressive therapy
- MALT-Marginal Lymphoma
  
  Phenotype
  Morphology
  Course
  Assoc
  Clinical
- MALT-Marginal Lymphoma
  
  Phenotype: CD19, CD20
  Morphology: Nodal = Marginal, Extra = MALT
  Course: Indolent
  Assoc: MALT = H pylor: stomach, Sjogrens Salivary, Hashimoto: in Thyroid
  Clinical: H pylor = Tx, Infx = cure, local for years, good prognosis
- Small Lymphomatic Lymphoma
  
  Phenotype
  Morphology
  Course
  Assoc
  Clinical
- Small Lymphomatic Lymphoma
  
  Phenotype: CD19, CD20
  Morphology: Nodal
  Course: Indolent
  Assoc: CLL
  Clinical: Incurable
- Lymphoma
  
  ALK Nodel
- Anaplastic Large Cell Lymphoma
- Lymphoma
  
  Splenomegaly
- Large Granular Leukemia Lymphoma
- Lymphoma
  
  Extramodal = skin, CNS demyelination
- Adult T Cell Lymphoma
- Lymphoma
  
  Skin Patch --> Plaque
- Mycosis Fungoides Lymphoma
- Lymphoma
  
  Leukemia from Start
- Sezary Cell Lymphoma
- Lymphoma
  
  Child
- Anaplastic Large Cell Lymphoma
- Lymphoma
  
  Looks like metastatic
- Anaplastic Large Cell Lymphoma
- Lymphoma
  
  Pancytopenia +RA
- Large Granular Leukemia Lymphoma
- Lymphoma
  
  HTLV -1, Carribean Hypercalcemia
- Adult T Cell Lymphoma
- Lymphoma
  
  Pautrier Microabsceses
- Mycosis Fungoides
- Lymphoma
  
  Red Man Exfoliation
- Sezary Cell Lymphoma
- Lymphoma
  
  Looks like fungal skin infection
- Mycosis Fungoides
- Lymphoma
  
  Nodal aka "Follicles"
- Follicular Common Lymphoma
- Lymphoma
  
  Nodal, Extranodal, eg. Waldyers Ring Abdomen
- Burkitt-African Endemic Lymphoma
- Lymphoma
  Extranodal: Face
- Burkitt-African Endemic Lymphoma
- Lymphoma
  
  Child abdomen, IC valve, ovaries
- Burkitt HIV Lymphoma
- Nodal or Extranodal Lymphoma
- Burkitt HIV Lymphoma
- Associations:
  
  EBV
- Burkitt-African Endemic Lymphoma
- Clinical:
  
  Potentially Curable, Starry Sky
- Burkitt-African Endemic Lymphoma
  Burkitt HIV Lymphoma
  Burkitt-Sporadic Lymphoma
- Associations:
  
  MALT= H pylor: stomach
  Sjogrens salivary
  Hashimoto: in thyroid
- MALT - Marginal Lymphoma
- Associations:
  
  CLL
- Small Lymphomatic Lymphoma