Pathogenic Microbiology

The ability of a pathogen to establish infection.

Damage done by the pathogen once the infection is established.

The ability of a pathogen to cause disease in another organism and the degree to which it is able to cause disease.

1) surface of mucosal epithelium, 2) epithelial cells, 3) deeper tissues- circulatory system

A specific portion of the body is infected.

An infection throughout the body; the infection resides in the bloodstream.

A systemic infection that starts off as a local infection.

One species is able to weaken the host.

Occurs because a primary infection has weakened the host.

Infection by more than one organism simultaneously.

An asymptomatic infection (not apparent)

Becomes apparent when resistance is lowered

bacteria ciruculating in the blood, replicating bacteria in blood, pus forming bacteria in blood, bacterial toxins in the blood.

1st symptoms occur. The patient starts to get sick. The disease may end here due to aquired immunity.

cause disease is a least some portion of normal individuals

cause disease in individuals with low immunity

Destroy blood cells

Allows for the spread through connective tissue.

Coagulates plasma

Dissolves plasma

an enzyme that is destructive of bacteria and functions as an antiseptic, found in tears, leukocytes, mucus, egg albumin, and certain plants.

synthesized by neutrophils and glandular epithelial cells, found in many human secretions (as tears and milk), and retarding bacterial and fungal growth

Inflammation and phagocytosis

Antibody and cell mediated immunity

Any of various large white blood cells that are formed in the bone marrow, circulate in the blood, and destroy pathogenic bacteria by phagocytosis. Monocytes develop into macrophages in various body tissues.

Any of various white blood cells that contain granular material in the cytoplasm and are immunologically active, especially in phagocytosis. (neutrophils)

Any of the nearly colorless cells found in the blood, lymph, and lymphoid tissues, constituting approximately 25 percent of white blood cells and including B cells, which function in humoral immunity, and T cells, which function in cellular immunity.

NADPH oxidase reacts with cytochrome B which forms hydrogen peroxide and other substances. This transforms chloride ions into hypochlorous ions killing the microbe.

lysozyme/ lactoferrin kill gram negative organism by disrupting the cell membrane.

Any substance that will produce a specific immune response when introduced into a host.

An immunological agent that increases the antigenic response.

Serum proteins formed in response to antigen stimulation. They react with antigens in a specific manner.

A localized region on the surface of an antigen that is capable of eliciting an immune response and of combining with a specific antibody to counter that response.