- Shuffle
Toggle OnToggle Off
- Alphabetize
Toggle OnToggle Off
- Front First
Toggle OnToggle Off
- Both Sides
Toggle OnToggle Off
Front
How to study your flashcards.
Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key
Up/Down arrow keys: Flip the card between the front and back.down keyup key
H key: Show hint (3rd side).h key
PLAY BUTTON
PLAY BUTTON
13 Cards in this Set
- Front
- Back
|
what medication is associated with causing pulmonary hypertension
|
anorexignes (aminorex fumarate of fenluramine) used for weight loss
|
|
what is the normal function of bone morphogenic protein
|
normally necessary for apoptosis for precapillary pulmonary arterioles
*decreased results in pulmonary hypertension |
|
an over-expression of what receptors trigger VSM hypertrophy and are associated with pulmonary HTN
|
serotonin receptors
|
|
down regulation of what receptors leads to pulmonary HTN
|
voltage-gated potassium channels
|
|
three genetic mutations associated with development pulmonary HTN
|
1. decreased BMPR2
2. over-expression of 5-HT receptors 3. down-regulation of potassium channel |
|
how could idiopathic pulmonary HTN lead to decreased PaO2
|
increased (A-a)O2 gradient due to decreased number of patent pulmonary vessels
|
|
differentiate central and peripheral cyanosis
|
central - arterial oxygen desaturation or abnormal Hb
peripheral - slow transit of blood or excessive oxygen utilization |
|
is cyanosis more likely to develop in severe polycythemia of anemia
|
polycythemia
|
|
differentiate what warm and cold recpetors activate
|
warm stimulate the anterior hypothalamus to increase cholinergic discharge
cold stimulate the posterior hypothalamus to increase sympathetic discharge |
|
activation of which part of the hypothalamus leads to increased body temperature
|
posterior hypothalamus
|
|
what are some physiologic events that cause the body's temperature to rise
|
1. induce fever via PGE2
2. increased cutaneous vasoconstriction 3. nonshivering thermogenesis - uncouple oxidative phosphorylation 4. shivering thermogenesis |
|
how does PGE2 induce fever
|
increases the release of cAMP which decreases the discharge rate of warm-sensitive neurons in the anterior hypothalamus
|
|
which medication can normalize the body's temperature even in the presence of systemic infection
|
glucocorticoids
*decreases synthesis pyrogens and indirectly decrease synthesis of PGE2 by inhibiting phosphlipase A2 |
