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14 Cards in this Set
- Front
- Back
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What two genetic defects are known to contribute to ADHD?
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defect in DRD4 gene
overexpression of DAT gene |
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Which region of the brain is implicated in selective attention symptoms of ADHD?
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dorsal nucleus accumbens (ACC)
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Which region of the brain is implicated in the deficit of sustained attention for problem-solving in ADHD?
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dorsolateral prefrontal cortex (DLPFC)
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Which region of the brain is implicated in hyperactivity in ADHD?
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prefrontal & supplementary motor cortices
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Which region of the brain is implicated in impulsivity in ADHD?
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orbital frontal cortex
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What *physical* abnormality may be observed in the brains of ADHD patients?
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reduced volume on the right prefrontal cortex, caudate, putamen, and globus pallidus
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List the four generic amphetamines used to treat ADHD:
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mixed amphetamine salts
dextroamphetamine lisdexamfetamine methamphetamine |
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Which has the shorter duration of action: amphetamine or methylphenidate?
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methylphenidate: 3-4 hours
(amphetamines: 4-5 hours) |
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Amphetamine (blocks / competes for) DAT and NET, whereas methylphenidate (blocks / competes for ) DAT and NET.
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amphetamine competes for...
methylphenidate blocks |
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Which adrenergic receptor is the target in the prefrontal cortex for ADHD drugs?
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postsynaptic alpha-2A
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Which ADHD drug side effect is the result of stimulation of the hypothalamus?
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appetite suppression (stimulation can cause feelings of satiety)
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Which ADHD drug side effect is the result of stimulation of the RAS?
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insomnia (stimulation can promote wakefulness)
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What is the mechanism of atomoxetine? Bonus points for naming the brand.
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atomoxetine inhibits NET
brand name: Strattera |
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What is the mechanism of guanfacine? Bonus points for naming the brand targeted for ADHD.
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guanfacine is an alpha-2A agonist.
brand name: Intuniv |
