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8 Cards in this Set
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Ergonovine
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Amine
-Class: agonist at alpha-1 and 5HT-2 Receptors -Therapeutic Use: Postpartum bleeding and labor induction when oxytocin-resistant -Important Side Effects: ergotism (vasoconstriction) leading to gangrene and bowel infarction -Important Interactions: Contraindicated in CV disease and pyschosis |
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Methylergonovine
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Amine
-Class: agonist at alpha-1 and 5HT-2 Receptors -Therapeutic Use: Postpartum bleeding and labor induction when oxytocin-resistant -Important Side Effects: ergotism (vasoconstriction) leading to gangrene and bowel infarction -Important Interactions: Contraindicated in CV disease and pyschosis |
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Dihydroergotamine:
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Amino Acid
-Class: Ergot Alkaloid (5HT agonist) Non-selective -Therapeutic Use: Moderate to severe migraine -Important Side Effects: ergotism (vasoconstriction) leading to gangrene and bowel infarction -Important Interactions: Contraindicated in CV disease and pyschosis |
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Ergotamine:
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Amino Acid
-Class: Ergot Alkaloid (5HT agonist) Non-selective -Therapeutic Use: Moderate to severe migraine -Important Side Effects: ergotism (vasoconstriction) leading to gangrene and bowel infarction -Important Interactions: Contraindicated in CV disease and pyschosis |
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Ergotamine Tartrate:
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Amino Acid
-Class: Ergot Alkaloid (5HT agonist) Non-selective -Therapeutic Use: Moderate to severe migraine -Important Side Effects: ergotism (vasoconstriction) leading to gangrene and bowel infarction -Important Interactions: Contraindicated in CV disease and pyschosis |
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Bromocriptine: (first ergot that was truly DA selective)
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Amino Acid
-Used in Hyperprolactinemia (DA inhibits prolactin secretion), Parkinsons, and Acromegaly -This is a DA D2 Rc Agonist, so it inhibits prolactin secretion, replaces lost DA in Parkinson’s patient, and lowers blood levels of growth hormone in patients w/ acromegaly. |
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Pergolide:
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Atypical
-Similar to Bromocriptine, selective for D2 and Serotonin, but 1000x more potent than Bromocriptine. -Indicated for adjunct treatment of levodopa/carbidopa in management of Parkinson’s -DA Rcs agonist at D1 and D2 Rcs, stimulates DA Rcs in Nigrostriatal System |
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Cabergoline
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Atypical
-Indicated for hyperprolactinemia disorders -Agonist at DA D2 Rcs, more selective than Bromocriptine and Pergolide. |
