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15 Cards in this Set
- Front
- Back
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lipid solubility of antimuscarinics depends on the presence of ______?
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quaternary amine group (permanently charged, poor lipid solubility)
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nonselective antimuscarinic, tertiary amine, T1/2 = 2h, duration of action is 4-8h and up to 72h in the eye
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atropine
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antimuscarinics act like ______ antagonists
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competitive (surmountable)
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DOC for motion sickness
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scopolamine
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antimuscarinics used in parkinsonism
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benztropine, biperiden, trihexyphenidyl
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antimuscarinics used for mydriasis (4)
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atropine, homatropine, cyclopentolate, tropicamide
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antimuscarinic used in asthma and COPD
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ipratropium
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why are some antimuscarinics used to bronchodilate, rather than beta agonists?
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cause less tachycardia and arrhythmias
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drugs used to reduce urgency in mild cystitis or to reduce bladder spasms s/p urologic surgery
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oxybutinin, tolterodine, darifenacin
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antidote for organophosphate poisoning
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atropine
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atropine toxic effects?
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dec sweating, salivation, lacrimation, urination (dry as a bone)
tachycardia constipation blurred vision hyperthermia (hot as a hare) dilation of cutaneous vessels (red as a beet) sedation, amnesia, delirium (mad as a hatter) |
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antimuscarinic agents are contraindicated in what pts?
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glaucoma, infants (fatal hyperthermia), men with BPH
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non-depolarizing neuromuscular blocker that produces competitive block at end plate nicotinic receptor causing flacccid paralysis, used as muscle relaxant in surgery
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tubocurarine
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depolarizing neuromuscular blocker that causes flaccid paralysis but may cause fasciculations during induction and may cause muscle pain after its use
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succinylcholine
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ChE regenerator used to treat pts exposed to parathion/malathion or nerve gases
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pralidoxime
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