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6 Cards in this Set
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What is D-penicillamine used for? What are the severe ADRs?
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Used to chelate heavy metals, and used to treat heavy metal poisoning. Severe ADRs are dermatitis to nephritis to aplastic anemia.
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What monoclonal antibody is fully human? That is used to treat Rheumatoid Arthritis, psoriatic arthritis, ankylosing spondylitis, and Crohn's disease. It reduces TNF in the body.
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Adalimumab
Ankur you might be down...tired...but don't give up keep pushing you got this! 600 show them! |
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What happens if you have a HGPRT deficiency?
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Results in an accumulation of Hypoxanthine and Guanine. This excess is metabolized by xanthine oxidase to uric acid. This can be prevented with Allopurinol.
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MOA of cancer resulting in gout?
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Because of overabundance of nucleic acid from dying malignant cells.
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At low doses probenecid does what?
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Low doses it competes with uric acid at the renal transporter causing increased uric acid levels.
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At high doses probenecid does what?
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High doses it acts to inhibit reabsorption of uric acid.
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