- Shuffle
Toggle OnToggle Off
- Alphabetize
Toggle OnToggle Off
- Front First
Toggle OnToggle Off
- Both Sides
Toggle OnToggle Off
Front
How to study your flashcards.
Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key
Up/Down arrow keys: Flip the card between the front and back.down keyup key
H key: Show hint (3rd side).h key
PLAY BUTTON
PLAY BUTTON
13 Cards in this Set
- Front
- Back
|
How do Statins work?
|
competitively inhibit HMG-CoA reductase
increase # of LDL receptors Dec. total chol, LDL, and TG short 1/2 |
|
Statins
|
Atorvastin
Fluvastatin Lovastatin Pravastatin Rosuvastatin Simvastatin |
|
Atorvastin
|
long t1/2 (11-14hr), can be administered anytime
|
|
Fluvastatin
|
LEAST likely to cause myopathy
|
|
Bile Acid-binding Resins
|
Tx for ppl not tolerating other drugs; additive effects with other drugs
no absorption in gut Cholestyramine Colestipol Colesevalam |
|
Ezetimibe
|
inhibits absorption of cholesterol
Decreases LDL (20%), decreases TG. Increases HDL alone or with statin |
|
Fibric Acid
|
Fenofibrate
Gemfibrozil increase VLDL clearance decrease TG levels |
|
Nicotinic acid (niacin)
|
fix-all
Decreases LDL and TG Increases HDL |
|
Best for decreasing LDL
|
statins-best
Niacin- good, complications Ezetimibe- good |
|
Best for increasing HDL
|
Niacin
|
|
Best for decreasing TG
|
Niacin-best, complications
Statins-good |
|
complications of Niacin
|
Gastric irritation, increased risk of myopathy
|
|
Niacin-statin combos
|
best- niacin and fluvastatin
worst- niacin and lovastatin |
