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3 Cards in this Set
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List 4 receptors of peripheral nervous system.
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Alpha 1-Smooth muscle contraction, vasoconstriction(sympathetic stimulation)
Alpha 2-Same as above Beta1-Cardiac stimulation, Beta2-bronchodiliation(agonists.) Never give a B2 antagonist. |
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First pass effect:
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The first-pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation. It is the fraction of lost drug during the process of absorption which is generally related to the liver and gut wall. Notable drugs that experience a significant first-pass effect are imipramine, morphine, propranolol, buprenorphine, diazepam, midazolam, demerol, cimetidine, and lidocaine.
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What are the 4 aspects of Pharmokineyics?
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Absorption - the process of a substance entering the blood circulation.
Distribution - the dispersion or dissemination of substances throughout the fluids and tissues of the body. Metabolism (or Biotransformation) - the irreversible transformation of parent compounds into daughter metabolites. Excretion (or Elimination) - the elimination of the substances from the body. In rare cases, some drugs irreversibly accumulate in body tissue. |
