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10 Cards in this Set
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what does T3 increase?
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respiration, carb metabolism, fat metabolism, body temperature, heart rate, neuromuscular activity
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what converts T4 --> T3?
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deiodinase enzymes in the target tissues
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difference between thyroglobullin and thyroxine-binding globulin?
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thyroglobulin: large quantities of thyroid hormone are stored as part of biosynth precursor thyroglobulin
TBG: T3/T4 circulate bound to TBG T4 binds tighter and that is why it is longer lived |
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what is thyroperoxidase used for?
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attatching I- to tyrosine
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liothyronine sodium
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replacement for T3
TIMES 3 = 9 must be given in multiple doses per day; greater potency and shorter 1/2 life more effective in treating hypothyrodic coma |
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levothyroxine
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replacement for T4
used more often than T3 (once daily pill) |
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MOA of methimazole, propylthiouracil (thiourelyenes)
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inhibit synthesis of tyrosine iodination... decreased synthesis of thyroid hormones
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methimazole
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most commonly prescribed, once daily dosing
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propythiouracil
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ADDED action of inhibiting peripheral de-iodination of T4 --> T3 (treatment of acute thyroid storm sometimes, more often long-term stabilization)
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iodide can surprisingly be used for what?
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hyperthyroidism.
relatively rapid inhibition of thyroid hormones (thyroid becomes smaller within 2 weeks) |
