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7 Cards in this Set
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Cyclosporine (CSA)
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binds to cyclophilins--> inhibits calcineurin-->prevents IL-2 and receptor production
tox: viral infections, lymphoma; nephrotoxic (prevent with mannitol) |
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Tacrolimus (FK506)
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binds to FK-binding protein --> inhibits calcineurin --> prevents IL-2/receptor production
tox: nephrotoxicty, periph. neuropathy, HTN, pleural effusion, hyperglc |
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Azathioprine
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6-MP antimetabolite precursor. toxic to prolif lymphocytes. interferes with synthesis of nucleic acids.
use: kidney tx, autoimmune. tox: BM suppression, allopurinol can increase mercaptopurine |
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Muromonab-CD3 (OKT3)
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Monoclonal Ab binds to CD3 on T cells
use: kidney tx tox: cytokine release. hypersensitivity rxn. |
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Sirolimus (rapamycin)
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binds to FK-binding protein --> binds to mTOR --> inhibits T-cell proliferation in response to IL-2
use: +CSA, steroids for kidney tx. tox: HL, thromboxytopenia, leukopenia |
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Mycophenolate mofetil
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inhibits de novo guanine synthesis.
blocks lymphocyte production. |
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Daclizumab
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monoclonal Ab with high affinity for IL-2 receptor on activated T cells
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