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14 Cards in this Set
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Haloperidol, fluphenazine, trifluoperazine
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MOA: block dopamine D2 receptors; HIGH potency
use: schizo, acute mania, Tourette's tox: EPS, Endocrine (galactorrhea), anti-HAM, NMS, tardive dyskinesia ***more neuro side effects |
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thioridazine, chlorpromazine
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MOA: block dopamine D2 receptors; LOW potency
use: schizo, Tourette's tox: EPS, Endocrine, anti-HAM, NMS, tardive dyskinesia ***more non-neuro side effects |
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Clozapine, Olanzapine, Risperidone, Aripiprazole, quetiapine, ziprasidone
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MOA: atypical; block 5-HT2, alpha, H1, and dopamine receptors
use: schizo, olanzapine (OCD, anxiety, depression, mania, tourette's) tox: clozapine can cause agranulocytosis and seizures |
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Lithium
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MOA:unknown; inhibition of phosphoinositol cascade?
use: mood stabilizer; bipolar d/o, SIADH tox: tremor, hypothyroid, polyuria (causes nephrogenic DI), teratogen, need close monitoring |
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Buspirone
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MOA: stim 5-HT1a receptor
use: generalized anxiety d/o, tox: doesnt cause sedation/addiction; no interaction with EtOH |
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Imipramine, amitriptyline, desipramine, nortriptyline, clomipramine, doxepin, amoxapine
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MOA: blocks NE and 5HT reuptake; TCA
use: depression, imipramine for bedwetting, clomipramine for OCD side effects: sedation, alpha-block, anticholinergic tox: convulsions, coma, cardiotoxicity, respiratory depression, hyperpyrexia give Nabicarb for CV tox |
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Fluoxetine
Paroxetine Sertraline Citalopram |
MOA: SSRIs
use: depression, OCD tox: GI, sexual, serotonin syndrome |
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Bupropion
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MOA: incr NE and dopamine
use: antidepressant tox: stimulant effects (tachy, insomnia); seizure in bulimics, HA |
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Venlafaxine
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MOA: 5HT, NE reuptake inhibitor
use: antidepressant, generalized anxiety d/o tox: HTN, stimulant, sedation, nausea |
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Duloxetine
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MOA: 5HT, NE reuptake inhibitor
use: antidepressant, diabetic peripheral neuropathy tox: HTN, stimulant, sedation, nausea |
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Mirtazapine
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MOA: alpha-2 antagonist (incr NE and 5HT release); 5HT2, 5HT3 receptor antagonist
use: antidepressant tox: sedation, incr appetite, wt. gain, dry mouth |
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Maprotiline
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MOA: blocks NE reuptake
use: antidepressant tox: sedation, orthostatic hypotension |
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Trazodone
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MOA: 5HT reuptake inhibitor
use: antidepressant (higher doses), insomnia tox: sedation, nausea, priapism, postural hypotension |
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Phenelzine
Tranylcypromine |
MOA: nonselective MAOI
use: atypical depression, anxiety, hypochondriasis tox: hypertensive crisis (if eat tyramine or use beta-agonist), CNS stimulation contra: SSRI or meperidine |
