- Shuffle
Toggle OnToggle Off
- Alphabetize
Toggle OnToggle Off
- Front First
Toggle OnToggle Off
- Both Sides
Toggle OnToggle Off
Front
How to study your flashcards.
Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key
Up/Down arrow keys: Flip the card between the front and back.down keyup key
H key: Show hint (3rd side).h key
PLAY BUTTON
PLAY BUTTON
22 Cards in this Set
- Front
- Back
|
What is adaptive anxiety?
|
-Appropriate rxn to danger
-Fear, arousal -Increased sympathetic activity |
|
What is maladaptive anxiety?
|
-Chronic, psychological stress
-Organ dysfunction, physical s/sx -GI, cardiac, substance abx |
|
Location of anxiety?
|
Amygdala
|
|
DOC for acute anxiety?
|
Bzd
|
|
DOC for panic disorder?
|
SSRIs
|
|
DOC for phobias?
|
SSRIs
|
|
DOC for OCD?
|
SSRIs
|
|
DOC for GAD?
|
Bzd, buspirone
|
|
DOC for PTSD?
|
Antidepressants
|
|
DOC for enuresis?
|
TCAs
|
|
How many stages of sleep?
|
1-4 plus REM
|
|
What are the effects of sleep-drugs on sleep?
|
Suppression of stage 3, slow wave, and REM
|
|
How many GABA receptors are there?
|
3
|
|
Which type of GABA receptor do barbs, bzds, and ETOH work at?
|
GABAa
|
|
BZD MOA?
|
-Work at site next to GABA receptors
-Works only when GABA is present in channel -At high doses, decreases GABA release for ceiling effect |
|
BZD pharmacokinetics
|
-Lipid soluble
-Readily enters brain |
|
BZDs for insomnia
|
-Flurazepam (Dalmane)
|
|
Barbs MOA
|
-Increases affinity of GABA to its receptor, increasing the time the Cl- channel is open
-Opens the Cl- independently of GABA -Linear dose response with no ceiling |
|
Antihistamine MOA
|
-Block H1 receptor
|
|
Zolpidem (Ambien) & Zalepon (Sonata) MOA
|
-Blocks BZD receptor subtype BZ1
|
|
Eszopiclone (Lunesta) MOA
|
-Similar to Ambien but blocks all BZ receptors
|
|
Ramelteon (Rozerem)
|
-Melatonin analogue
-Promotes sleepiness w/o GABA effect -No effect on REM |
