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29 Cards in this Set
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|
-cillin
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Penicillins (class of Beta Lactams)
Inhibit transpeptidation, cell wall synthesis. |
=Natural Peni- (G,V) =Penicillinase resistent Methi- Cloxa- =extended range Ampi- Amoxi- =psudomonal Carbeni- Ticar- Piper- |
|
Cef-
|
Cephalosporins (class of Beta Lactams)
Inhibit transpeptidation, cell wall synthesis. |
1st Gen -azolin 2nd -otetan -otoxitin -uroxime also Loracarbef 3rd -triazone -trazidime -operazone 4th -epime |
|
-penem
|
Carbapenems (class of Beta Lactams)
Inhibit transpeptidation, cell wall synthesis. |
Imi- Mero- Erta- |
|
-cycline
|
Tetracyclines/Glycylcylcine
Bind 30S and inhibit bacterial protein synthesis |
=Tetra Tetra- Doxy- =Glycyl Tige- |
|
-THROmycin
|
Macrolides/Ketolides.
Bind 50S and inhibit bacterial protein synthesis. |
=Macrolides Ery- Clari- Azi- =Ketolide Teli- |
|
-oxazole
|
Sulfonamides.
Inhibit dihydropteroate synthase. (Trimethoprim inhibits dhpt reductase) Prevent folate synthese, ergo nucleic acid synthesis |
Sulfis- Sulfameth- |
|
-floxacin
|
Fluoroquinolones.
Inhibit DNA gyrase. Bc G- |
Cipro- Lexo- |
|
Rifa-
|
Rifamycins.
Inhibit RNA synthesis. |
|
|
-mantadine
|
Inhibits viral uncoating via M2 protein.
Treats Influenza A |
A- Ri- |
|
-amivir
|
Block viral budding.
Inhibits viral neuraminidase, prevents cleavage of sialic acid. Treats Influenza A & B. |
Zan- Oselt- |
|
-ciclovir
-cyclovir |
Guanosine (guanine nucleoside) analog.
Acyclovirs and analogs treat Hepres simplex 1& 2 and varicella zoster. Ganciclovir is used for CMV. |
Acy- Valacy- Penci- Famci- Ganci- |
|
-cavir
|
Guanosine analog nucleoSide reverse transcriptase inhibitors.
Abacavir = HIV Entecavir = HBV |
Aba- Ente- |
|
-fovir
|
NucleoTide reverse transcriptase inhibitors.
Tenofovir = HIV Cidofovir = CMV Adefovir = HBV |
Teno- Cido- Ade- |
|
-navir
|
HIV protease inhibitors.
Block cleavage of gag-pol precursor. |
Amprenavir/Fosamprenavir Atazanavir Darunavir Indinavir Lopinavir Nelfinavir Ritonavir Saquinavir Tipranavir |
|
-conazole
|
Azoles (antifungal).
Inhibit 14-alpha-demethylase (a P-450). Prevent ergosterol synthesis |
Flu- Intra- Keto- Poso- Vori- |
|
-afine
|
Allylamines.
Inhibit fungal squalene oxidase. |
Naft- Terbin- Buten- |
|
-fungin
|
Echinocandins.
Inhibit glucan synthase. Glucan in used in fungal cell wall. |
Caspo- Mica- |
|
-mustine
|
Chloroethyl nitrosoureas.
Heterobifunctional alkylating agents for cancer chemo. Also can cause DNA crosslinking and carbamoylation of proteins. CNS available. |
Car- Lo- |
|
-platin
|
Platinum coorditing alkylating agents for cancer chemo.
Testicular, ocarian, heand and neck cancers. |
Cis- Oxali- Carbo- |
|
Vin-
|
Vinca Alkaloids (from plants).
Bind to tubulin, favor depolymerization. Tox: Granulocytopenia. |
-cristine -blastine -orelbine |
|
-taxel
|
Taxanes: diterpene antineoplastics from western yew tree.
Bind to tubulin, make it super stable (inhibit dynamic processes like mitosis). Tox: neutropenia, mucositis. |
Pacli- Doce- |
|
-poside
|
Epipodophyllotoxins from mandrake plant.
Inhibit topoisomerase II. Treat Hodgkin's, diffuse histiocytic lymphoma and SCC of lung. Tox: leukopenia, thrombocytopenia |
Eto- Teni- |
|
-tecan
|
Camptothecins.
Inhibit topoisomerase I. Irino: metastatic colon cancer Topo: ovarian and SCC of lung |
Irino- Topo- |
|
-rubicin
|
Antrhacycline antibiotics used in cancer chemotherapy.
Mech: DNA intercalation/single stranded breaks. |
Dauno- Doxo- |
|
-tinib
|
Tyrosine kinase inhibitors
Ima: Blocks c-abl kinase (translocated to bcr region of ch22). Treats CML and Ph+ ALL Erlo, Gefi: inhibits EGF receptor. Treats non-SCC of lung and pancreatic cancer |
Ima- Erlo- Gefi- |
|
-mab (chemo)
|
Monoclonal antibodioes
Ceruxi: EGF receptor - head, neck, metastatic colon cancer Trastuzu: p185-her2 positive breast cancer. Bevacizu: VEGF receptor - inhibits angiogenesis in lung, colon cancer. Rituxi: anti-CD20 - non-Hodgkins B cell lymphoma Gemtuzu: anti CD33 |
Ceruxi- Trastuzu- Bevacizu- Rituxi- Gemtuzu- |
|
-trozole
|
Selective & reversible aromatase inhibitors.
Treat breast cancer. Used for only postmenopausal women. |
Anas- Le- also Exemestane |
|
-quine
|
Malarials
|
Meflo- Chloro- Also Quinine and Quindidine |
|
-bendazole
|
Benzimadozoles.
Bind beta-tubulin, inhibit microtubule polymerization. Anti-Nematodes: T. trichiura, Ascaris, Capillariasis, Necator americanus |
Al- Me- Thia- |
