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25 Cards in this Set
- Front
- Back
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what is ciprofloxacin?
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2nd generation fluoroquinolone - DNA gyrase inhibition
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what is the spectrum of ciprofloxacin?
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extended - mostly used against pseudomonas aeruginosa
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how is ciprofloxacin given?
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orally
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what are the ADRs of ciprofloxacin?
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crystalluria, cartilage damage - do not give to pregnant women or kids <18
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what is special about ciprofloxacin?
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penetrates well into bone and soft tissue; used for prostitis and GI infection; interacts with metal ions found in antacids
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what is levofloxacin?
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3rd generation fluoroquinolone - DNA gyrase inhibitor
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what is the spectrum of levofloxacin?
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extended, better + activity - especially strep pneumo
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how is levofloxacin given?
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orally
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what are the ADRs of levofloxacin?
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crystalluria, cartilage damage - do not give to pregnant women or kids <18
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what is special about levofloxacin?
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may cause prolonged QT so watch cardiac patients; penetrates well into bone and soft tissue, used for prostitis and GI infections; don't take with antacids
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what is moxifloxacin?
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4th generation fluoroquinolone - DNA gyrase inhibition
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what is the spectrum of moxifloxacin?
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extended - better anaerobic activity
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how is moxifloxacin given?
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orally
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what are the ADRs of moxifloxacin?
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may cause prolonged QT so watch cardiac patients; penetrates well into bone and soft tissue, used for prostitis and GI infections; don't take with antacids
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what is rifampin?
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rifamycin - inhibits RNA polymerase
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what is the spectrum of rifamycin?
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broad - mainly mycobacterial
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how is rifampin given?
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orally - good for travelers diarrhea
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what are the ADRs of rifampin?
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failure of OC!, but well tolerated
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what is special about rifampin?
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resistence occurs rapidly - must combine with other drugs; used as prophylaxis for meningitis, and to treat leprosy
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what is metronidazole?
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froms toxic metabolite that damages DNA - bactericidial and anti-protozoal
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what is the spectrum of metronidazole?
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extended - anaerobes
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how is metronidazole given?
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IM
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what are the ADRs of metronidazole?
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CNS depression and EtOH intolerance
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what is special about metronidazole?
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Works well against B. fragilis, C. difficile, H. pylori, trichomonas and the DOC for entamoeba Histolytica and anaerobic bacteria
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what type of killing do fluoroquinolones do?
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bacteriocidal
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