- Shuffle
Toggle OnToggle Off
- Alphabetize
Toggle OnToggle Off
- Front First
Toggle OnToggle Off
- Both Sides
Toggle OnToggle Off
Front
How to study your flashcards.
Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key
Up/Down arrow keys: Flip the card between the front and back.down keyup key
H key: Show hint (3rd side).h key
PLAY BUTTON
PLAY BUTTON
8 Cards in this Set
- Front
- Back
|
Isoniazid
|
Most important TB drug. Activatied by catalase9peroxidase. Inhibits mycolic acid synthesis which is component of cell wall. Cidal to organisms. Resistance is bc of loss of catalase/peroxidase gene. Distribultes in total body water including intracellularly. N-acetylation is teh rate limiting step for metabolism and varies in the population. This has no effect on efficacy but slow ones have higher incidence of peripheral neuropathy.
|
|
Isoniazid adverse effects
|
major one is peripheral nephropathy by depleation of B6 (pyridoxine). Supplementation prevents. Can induce hepatitis. Most people have elevation of serum liver enzymes but only a few go into hepatits.
|
|
Rifampin
|
2nd most important TB drug. Inhibits DNA-dependent RNA polymerase. Highly bacterial specific.
|
|
Adverse of Rifampin
|
Normals plus drug induced hepatits. Orange urine and secretions. Potent inducer of CYP3A4.
|
|
Ethambutol
|
Ocular toxicity. Dose related. Decrease in visual acuity or decrease in visual fields. Red/green color problems. Hyperuricemia. Don't worry about MOA.
|
|
Pyrazinamide
|
Synthetic pyrazine analog of nicotinamide. Exhibits bactericidal activity in vitro only at slightly acidic pH. Hyperuricemia and rarely gout. Dose-related hepatotoxicity is rare too.
|
|
Streptomycin
|
Aminoglycoside. Ototoxic, nephrotoxic. Not absorbed orally.
|
|
Leprosy drugs.
|
Dapsone, rifampin, clofazimine.
|
