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What are the mechanisms of Class IA drugs? Used for?
Sa channel blockade
K channel blockade
Decreased conduction velocity (QRS widening)
Prolong repolarization (QT prolongation)
Used for Afib and ventricular arrhythmias
A/e of IA?
GI: N/v/d
Fever
hypotension
Tinnitis, blurred vision, headache
Mechansisms of Class IB?
Na channel blockade
Decreased conduction velocity
Shorten repolarization (shorten QT)
Used for prevention and termination of ventricular arrhythmias
A/e of IB?
GI
agranulocytosis
Diplopia
drowsiness
Mechanisms of IC?
Na channel blockade
Decreased conduction velocity (QRS widening)
Inidcations for IC?
A fib, ventricular arrhythmias, chronic suppression of both
A/e of IC?
CNS
HA
Bradycardia
Proarrhythmia (vtach)
N/v
Indication and mechanism of II?
Indicated for Afib, ventricular arrhythmias
MOA: Beta blockade
No change in repolarization
Slows conduction through AV node
Decrased HR
A/e of II?
drowsiness, depression, hypotension, brady, heart block,
Exacerbation of HF
Indication and mechanism of class III?
Indicated for A fib and ventricular arrhythmias to convert to NSR.
K-channel blockade
Prolongs repolarization (QT)
A/e for class III?
Thyroid abnormalities
Eye problmes
Neurologic problems
Pulmonary toxicity
GI