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14 Cards in this Set
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- Back
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What is the general mechanism of action of fluroquinolones?
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- interfere with DNA gyrase so bacteria can't sythesize DNA
- Bactericidal |
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What are the names of three popular fluorquinolones?
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- ciprofloxacin (Cipro)
- Enoxacin (penetrex) - gatifloxacin (tequin) |
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What are the ROA for fluorquinolones?
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- Oral and IV
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What is the dose for Ciproflaxin?
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- 500-750 q12 oral
- 400 q12h IV |
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What is the dose for enoxacin?
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- 200-400 q12h for 1-2 wk
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What are fluorquinolones used for?
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- UTIs, prostatitis, gonorrhea, pneumonia, infections of bones and joints, anthrax
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What are the particularly nasty adverse effects of fluoroquinolones?
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- nephrotoxicity, neuropsychiatric effects, cardiac abnormalities, liver dysfunction, damaged cartilage in children
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What patient would benefit most from fluorquinolones?
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- not children or preggers/ lactating
- UTIs, prstatitis, gonorrhea (junk problem) |
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What is the mech of action of tetracyclines?
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- Bacterial ribosome binding
- broad spectrum - mainly baceriostatic |
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What are the names of important tetracylcines?
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- chlortetracycline (aureomycin)
- tetracycline (achromycin, sumycin, panmycin, steclin) |
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What are the uses of tetracyclines?
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- Rocky mountain spotted fever
- typhus fever - chlamydial infections - cholera -brucellosis - tularemia - amebiasis - alternative to penicllins for STIs |
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What are the common adverse effects of tetracycline?
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- candidiasis (superinfection)
- graying in childrens developping teeth |
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What are the serious adverse effects of tetracyline?
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- impaired bone growth
- harm unborn baby or nursing infant - makes birth control pill not work |
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Which patients wouldn't benefit from tetracyline?
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- liver disease or children < 8
- one on phenytoin and barbiturates |
