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8 Cards in this Set
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- Back
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How is the blood brain barrier different from ordinary capillaries?
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does not allow free drug distribution, tight junctions limit drug movement out of capillaries. ABC transporters rapidly transport drug from brain back into the capillary
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What is the equation for Vd?
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Vd = D / Cp
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Vd cannot exceed total body water (true/false)
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false (Vd is an artificial concept and will exceed TBW if a drug is concentrated outside of the plasma compartment)
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The larger the Vd the _________ a drug will stay in the body
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longer
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Albumin has a preference for acidic or basic drugs?
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acidic
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Alpha 1-acid glycoprotein has a preference for acidic or basic drugs?
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basic
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Protein binding _________ the rate of elimination
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decreases
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Albumin levels __________ with age
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decrease
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