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8 Cards in this Set
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- Back
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D2 receptor blockage
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Haloperidol
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D 4 receptor blockage
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Clozapine
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Alpha1 r blockage
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Thioridazine
Clozapine Ziprasidone |
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5-HT2 Block
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Clozapine
Olanzapine Quetiapine |
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M Block
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Thioridazine
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Lithium
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The mechanism of action of lithium is not well defined. The drug inhibits several enzymes involved in the recycling of neuronal membrane phosphoinositides. This action may result in depletion of the second messenger source, phosphatidylinosityl bisphosphate (PIP2), which, in turn, would decrease generation of inositol trisphosphate (IP 3) and diacylglycerol (DAG).
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TREATMENT OF MANIA
Valproic acid |
Valproic acid has antimanic effects equivalent to those of lithium and is now widely used in the Unites States for this indication, often as a first choice in acute illness
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TREATMENT OF MANIA
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The antiseizure drugs carbamazepine and lamotrigine are also used both in acute mania and for prophylaxis in the depressive phase.
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