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9 Cards in this Set
- Front
- Back
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4 Components of Pharmacokinetics
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Absorption
Distribution Metabolism Excretion |
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Absorption
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How body absorbs a drug
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Distribution
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How to get to target cell (Transportation)
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Metabolism
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How a drug is broken down to be used
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Excretion
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How a drug leaves the body
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Factors affecting absorption
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Route of admin
drug formulation, dosage Digestive motility, enzymes Blood flow at admin site Degree of ionization pH Drug-Drug/Food interactions Supplements/Herbs |
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Metabolism
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(Biotransformation)
Biochemical rx's Liver is primary site Changes drug to be excreted |
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1st Pass Effect
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Drugs are absorbed ->enter hepatic portal circ. directly to liver -> enzymes metabolize drug to inactive form -> leaves liver -> distributed to general circ.
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Primary Site of Excretion
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Kidneys
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