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9 Cards in this Set

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GHRH Stimulants
Dopamine
Serotonin
alpha-adrergic agonists
Somatostatin
GHRH Inhibitors
beta adrenergic agonists
free fatty acids
IGF-1
GH
Somatorelin
GHRH analog
Ghrelin
causes GH release
what increases circulating GH binding proteins
Obesity
estrogen
what are the therapy options for GH hypersecretion?
tumor irradiation/surgery
dopamine agonists (bromocriptine, cabergolide)
somatostatin analogs (octreotide, lanreotide)
GH receptor antagnoist (Pegvisomant)
What should be noted before use of dopamine agonists in treatment of GH hypersecretion?
Must note health status of patient before use
What are some cautions of Pegvisomant treatment?
Pegvisomant = GH receptor antagonist
should not be used in patient with liver damage (elevated transaminase levels)
careful follow up of pituitary by MRI mandatory since interferes with IGF-1 mediated inhibition and can lead to GH-secreting adenomas
what is the consequence of GH hyposecretion in adults?
decreased muscle mass
increased fat mass
decreased bone mineral density