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25 Cards in this Set
- Front
- Back
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What is the effects and clinical uses of muscarinic agonists called?
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parasympathomimetics
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What is the effects and clinical uses of muscarinic antagonists called?
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parasympatholytics
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The effects of M1 and M5 is?
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Depolarisation
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The effect of M2 and M4 is?
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Inhibition
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The effect of M3 is?
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Stimulation
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M4 and M5 are (Neutral/Cardiac/Glandular/CNS/CNS)?
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CNS
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M1 is (Neural/Cardiac/Glandular/CNS/CNS)?
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Neural
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M2 is (Neutral/Cardiac/Glandular/CNS/CNS)?
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Cardiac
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M3 is (Neutral/Cardiac/Glandular/CNS/CNS)?
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Glandular
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M1 can be found in
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CNS, autonomic, ganglia
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M2 is found in
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atria, SA and AV node
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What is the effect of M2 on the heart?
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Slowing of heart rate (bradycardia)
Reduced contractility of atria Slowing of conduction though A-V node |
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What muscarinic agonist subunit works on the blood vessels?
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M3
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What is the effect of M3 on glandular secretion?
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Increased production of salivary, lacrymal and bronchial secretions
Increased gastric secretion and sweating |
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What is the effect of M3 on non-vascular smooth muscle
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Increased peristaltic activity in gut
Constriction of bronchioles Bladder – contraction of detrusor muscle and relaxation of sphincter |
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What is the clinical use of pilocarpine drops
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Glaucoma
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What is given to cause a stimulation of GIT activity and bladder following surgery
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oral bethanecol
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cycloplegia (cannot focus for near vision) occurs from muscarinic (agonist/antagonist)
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antagonist
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What is the effect of muscarinic antagonists of atropine on the CNS?
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agitation, confusion, hallucinations and coma
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What is the effect muscarinic antagonists of Hyoscine on the CNS?
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sedation but high doses produce effects similar to atropine
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Hyoscine is clinical use to prevent?
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motion sickness
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Which muscarinic is used as a bronchiodilator?
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Ipratropium in some cases of asthma and chronic bronchitis
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Which muscarinic is used in cardiac arrest?
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Atropine used to reverse bradycardia
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Which muscarinic is used in Parkinsons disease?
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Benzatropine used to reduce tremour
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빠르다
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to be fast/quick
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