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6 Cards in this Set

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  • Back
Nicotine MOA?
Nicotine binds alpha4 beta2 nicotinic Ach receptor in VTA releasing DA in NA
Tolerence and tobacco?
Up-regulation and desensitization of nAch receptors
Nicotine Replacement therapies?
Gum, patch, nasal spray, inhailer, lozenge
CI with recent MI, Severe angina and arrhythmias
Bupropion or Smoking?
CI with seizures, bulimia, anorexia
Varenicline?
alpha4 beta2 partial agonist, in presence of nicotine, bllocks effects, can devlope mild physical dependence
CI: Pregnars, lactars, or kids
Pschiatric co-morbidities?
Schizophrenia, MDD, dysthymia, bipolar, panic disorder, PTSD, ADHD, substance abuse