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what type of bug is pseudomonas?
g(-) bacilli rod
Features of PA
- G-rod
-OXIDASE POSITIVE (differs from enteric organisms that r (-) and that smell bad)
- AEROBIC (does NOT FERMENT ANYTHING)
Distinguishing features of PA
-OXIDASE +
-G- ROD
-NONFERMENTING
-GRAPE LIKE ODOR
- SLIME LAYER (esp. bad for cf pats)
- no lactose fermenting on EMB or MacConkey
where is PA typically found?
ubiquitous in watery environments or products
transmission of PA?
- water aerosols
- raw veggies
- flowers (prohibited in burn units)
pathogenesis and virulence factors of PA
- ENDOTOXIN --> inflmmtn/g(-) shock septicemia
- EXOTOXIN A-ADP --> RIBOSYLATES EF-2 (elongation factor 2 --> prevents protein synthesis)
- liver is primary target of exotoxin
- capsule / slime layer
Diseases that PA causes in people?
hlthy humans: transient gi fx, hot tub folliculitis, eye ulcers
burn pats --> skin cellulitis --> (blue-green pus formation) --> septicemia
- neutropenic pats --> pneumonia / septicemia
what other conditions is ripe for PA development? what type of immune deficiency?
-->Chronic granulomatous disease patients --> recurrent pneuonias and septicemias
--> septicemias --> black,necrotic skin lesions --> "ecthyma gangrenosum"
--> catheter pats --> UTIS
--> cystic fibrosis --> recurrent pneumonias (always high in slime producing bacterias)
differential dx for pa
- s.aureus
- g (-) rods
- klebsiella pneumoniae
PA dx
gram stain and culture
Rx for PA
- ANTIPSEUDOMONAL PENICILLIN (pipericillin ?)
PA prevention?
- pasteurize or disinfect water logged stuff
- hand wash
- remove catheters quickly
- NO FLOWERS OR RAW VEGGIES IN BURN UNITS
Pseudomonas Vigenette clues
Gram (-), Oxidase (+) aerobic bacillus, blue-green pigments with a FRUITY ODOR
- burn patients/ infections --> blue-green PUS--> smells fruity
- typical pneumonia in CGD / CF patients
UTI's in catheter pats