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12 Cards in this Set
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- Back
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At what 1/2 life can you begin to give a drug once a day?
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Anything greater then 7 hours
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What are Sulfonamides used with and how do they work?
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Typically combined with w/ Trimethoprim
Bacteriostatic inhibitors of Folic Acid synthesis, they compete with PABA to inhibit Dihydropteroate enzyme |
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How does resistance occur to Sulfonamides?
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Incresed or altered production of Dihydropteroate enzyme or
Mutation of PABA binding site |
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What does Trimethoprim plus a Sulfonamide do?
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Results in a sequential blockade of folate synthesis, and the combination is bactericidal
Highly used for UTI's |
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What is the main indication for Sulfonamides alone?
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Gram (-): E. Coli and P. Mirababilis for UNCOMPLICATED UTI's
Generaly NOT used alone for Gram (+) |
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What are Sulfisoxazole and Sulfamethoxazole used for?
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Systemic use, Primarily for UTI's
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What is Sulfacetamide primarily used for?
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Topical use in opthalmic drops for Eye Infections
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What are the ADR's for Sulfonamides?
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Rash, Hives, Photosensitivity and MORE serious STEVENS-JOHNSON SYNDROME- sloughing off of skin can be fatal
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Why would you NOT want to use Sulfonamides with babies?
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Because can displace bilirubin from binding and cause kernicterus (brain damage)
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What is Trimethoprim and Sulfonamide combo not effective for?
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Enterococci and Pseudomonas
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What is the Trimethoprim and Sulfonamide the DOC for?
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Pneumocystis Kiroveci
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What are the adverse effects of Trimethoprim and Sulfonamide combo?
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75% of incidences involve increased skin effects/rashs
Increased ADR in AIDs pts. |
