rav endocrinology ACTH DEF

By actea8, Jul 2011

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ACTH deficiency causes	hypocortisolism, with symptoms of nausea, vomiting, weakness, fatigue, fever, and hypotension.
Mineralocorticoids are not generally affected by this deficiency because	they are controlled by the renin-angiotensin system, so hyperkalemia is not present.
In women, reduced adrenal androgens can	decrease libido and cause loss of axillary and pubic hair.
However, patients with significant ACTH and cortisol deficiency may occasionally	be asymptomatic.
The most common cause of ACTH deficiency is	suppression of ACTH secretion with exogenous corticosteroids.
If another cause is responsible, ACTH deficiency usually occurs in combination with	the loss of other pituitary hormones.
Acquired isolated ACTH deficiency can occur, however, particularly in	women with lymphocytic hypophysitis.
megestrol acetate for appetite stimulation can occasionally	suppress the secretion of ACTH and lead to its deficiency.

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