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* The underlying mechanism of hypercalcemia in granulomatous diseases involves
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Treat hypercalcemia associated with sarcoidosis.
Key Point * The underlying mechanism of hypercalcemia in granulomatous diseases involves excess production of 1α-hydroxylase, which converts 25-hydroxy vitamin D to 1,25-dihydroxy vitamin D; corticosteroid administration diminishes this hypercalcemia. |
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With sarcoidosis, hypercalcemia may be secondary to increased
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With sarcoidosis, hypercalcemia may be secondary to increased intestinal absorption induced by excessive amounts of 1,25-dihydroxy vitamin D. In patients with this disorder, 1,25-dihydroxy vitamin D production can be diminished by using corticosteroids, such as prednisone, as the initial therapy.
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