ravilya2013 TTP

microangiopathic hemolytic anemia,
thrombocytopenia with normal coagulation,
and central nervous system symptoms,
the principal triad of thrombotic thrombocytopenic purpura (TTP); renal failure and fever compose the pentad of symptoms.

Plasma exchange is the principal treatment modality for TTP and should be initiated as soon as possible to decrease patient morbidity.
Plasma exchange reverses the platelet consumption that is responsible for the thrombus formation causing the findings associated with TTP. It is acceptable to initiate plasma exchange even in circumstances when the diagnosis is in question, only to be stopped when an alternative diagnosis is established.

when unexplained hemolytic anemia and thrombocytopenia in P with renal failure( look his labs!) and neurological symptoms ( confusion , head aches)
micro angiopatic hemolytic anemia ( MANA)-- check fragmented cells in peripheral smear)

yes, for unknowns reason

hialine microthrombi occluded small vessels maybe in in any organs
they cause they mechanical damage to RBC( shistocytes on Peripheral smea

no coagulation factors consumption so, PT and aPTT will be normal

deficiency of or AB against specific von Willibrandt factor cleaving protease( ADAMS 13)