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7 Cards in this Set

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what will see on histo
see small lyphocytes with plasmacytoids lymphocytes and plasma cells, indolent (treat like indolent lymphoma).
fatigue, lymphadenopathy, bleeding.
Unlike MM,what is there
Unlike MM, there's hyperviscosity and no lytic bone pain
clinical
indolent (treat like indolent lymphoma).
fatigue, lymphadenopathy, bleeding.
Most patients
with this disease present with symptoms
Most patients
with this disease present with symptoms
of hyperviscosity (Raynaud’s phenomenon and
visual disturbances), and protein-protein interaction
(platelet dysfunction).
Diagnosis requires
Diagnosis requires
the demonstration of an IgM spike on
plasma electrophoresis, as well as infiltration of
bone marrow with plasmacytoid lymphocytes.
to control hyperviscosity... how to
Plasmapheresis is used to control hyperviscosity
initially because response to chemotherapy
can take several weeks.
Treatment regimens involve
Treatment regimens involve
the same chemotherapeutics as those
used for multiple myeloma, including alkylating
agents and prednisone. Overall mean survival
is 5 years