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24 Cards in this Set
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- Back
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Define Interstitial Lung Disease
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Group of pathologically similar disease states that involve extensive alteration and disruption of ***distal lung parenchyma***
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what 2 lung structures are affected in interstitial lung disease?
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Parenchyma
Connective tissue |
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What is the clinical presentation of interstitial lung disease?
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Primary complaint is dyspnea usually first with exertion then at rest
Many have a dry spasmodic cough May hear “Velcro” rales – generally in inspiration Later in course can see digital clubbing Can have a normal CXR initially Chest pain, wheeze and hemoptysis are unusual presenting complaints |
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if you hear a velcro sound in inspiration what should you be thinking
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interstitial lung disease
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Peribronchovascular sheaths
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connective tissue surrounding the bronchi and the vascular bundles
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Interlobular septae
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tissue in between the secondary lobules
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Causes of ILD ?
*** read this |
Collagen Vascular Diseases
Drug induced Occupational/enviormental *** |
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please give an overview of interstitial lung disease, giving the 4 steps
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1) Epithelial basement cell membrane injury
2) Influx of inflammatory cells 3) Increased expression of fibroblasts 4) Accumulation of extra cellular matrix Continuation of injury by cascade of pro-inflammatory cytokines and/or continued exposure to inciting drug or event |
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how do you get a diagnosis of interstitial lung disease?
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BIOPSY of lung
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what is the treatment for Talc lung disease (3)
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Oxygen & avoidance of initiating factors
Steroids to reverse cellular inflammation and fibroblast proliferation |
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if you see a noncaseating granuloma in the lung what should you be thinking?
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Sarcoidosis
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Chronic multi-organ inflammatory disorder of unknown etiology
Tissue infiltration by monocytes and lymphocytes and noncaseating granulomas which mainly affect the lungs and lymphatics this describes? |
sarcoidosis
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what are the possible outcomes of sarcoidosis?
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1/3 will have spontaneous remission
1/3 will not progress 1/3 progress in organ dysfunction |
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what guides various biopsy techniques?
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Location of lymph node involvement
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what is lupus pernio?
what is it consistent with? |
Lupus pernio – violaceous indurating skin lesion affective chiefly the nose and facial skin
consistent with Chronic Disease (sarcoidoisis) |
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inhalation and deposition of coal dust into the lungs causes what?
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Pneumoconiosis
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the following describes....
Small rounded opacities on CXR Occur after normal dust particle clearing mechanisms are overwhelmed Nodules are a collection of dust-laden macrophages around a dilated bronchiole Involved with focal enlargement of local airspaces - emphysema |
Simple Coal Workers Pneumoconiosis
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what distinuguishes progressive massive fibrosis from simple coal worker pneumoconiosis?
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Diagnosis of Progressive Massive Fibrosis made when one of the coal macules reaches 2cm or greater in size
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if you are coughing up black stuff what do you have
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Progressive Massive Fibrosis
or you are a crack smoker (I SMOKE ROCKS) |
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if you have exposure to silica (such as coal worker or power sander) what do you have an increased risk for?
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TB
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dude works in the boiler room of a shipyard. What is this uka gonna get?
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Asbestosis
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egg shell calcification of hilar nodes is associated with?
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Silicosis
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What are the 2 types of pneumoconiosis?
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Coal Workers Pneumoconiosis
Progressive Massive Fibrosis (more likely to progress even after removal of exposure) |
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How do you define the etiology of interstitial lung disease?
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Biopsy
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